Asthma-Chronic Obstructive Pulmonary Disease Overlap Syndrome: Nothing New Under the Sun

Overview

Journal Immunol Allergy Clin North Am

Specialty Allergy & Immunology

Date 2016 Jul 13

PMID 27401623

Citations 8

Authors

Nirupama Putcha

Robert A Wise

Affiliations

Soon will be listed here.

Abstract

The debate about whether asthma and chronic obstructive pulmonary disease (COPD) are distinct clinical syndromes is not new; there is heightened interest in understanding the group of individuals with obstructive lung disease who seem to have elements of both conditions because recent studies have demonstrated increased risk for respiratory events and exacerbations. We describe the clinical characteristics of this subtype of disease and suggest 4 working definitions of individuals who would fall into the asthma-COPD overlap category. Understanding the mechanisms underlying these subtypes will hopefully lead into a better understanding of therapeutic strategies that can target specific pathobiologic pathways.

Citing Articles

Effects of a Peptide Derived from the Primary Sequence of a Kallikrein Inhibitor Isolated from (pep-BbKI) in an Asthma-COPD Overlap (ACO) Model.

da Silva L, Barbosa J, Joao J, Fukuzaki S, do Nascimento Camargo L, Dos Santos T Int J Mol Sci. 2023; 24(14).

PMID: 37511021 PMC: 10379932. DOI: 10.3390/ijms241411261.

ACO (Asthma-COPD Overlap) Is Independent from COPD: The Case in Favour.

Calverley P, Walker P Diagnostics (Basel). 2021; 11(7).

PMID: 34208874 PMC: 8304638. DOI: 10.3390/diagnostics11071189.

Asthma-COPD overlap: current understanding and the utility of experimental models.

Tu X, Donovan C, Kim R, Wark P, Horvat J, Hansbro P Eur Respir Rev. 2021; 30(159).

PMID: 33597123 PMC: 9488725. DOI: 10.1183/16000617.0185-2019.

Asthma-COPD overlap in World Trade Center Health Registry enrollees, 2015-2016.

Haghighi A, Cone J, Li J, de la Hoz R J Asthma. 2020; 58(11):1415-1423.

PMID: 32930623 PMC: 8607507. DOI: 10.1080/02770903.2020.1817935.

Flow and volume response to bronchodilator in patients with COPD.

Vigna M, Aiello M, Bertorelli G, Crisafulli E, Chetta A Acta Biomed. 2018; 89(3):332-336.

PMID: 30333454 PMC: 6502113. DOI: 10.23750/abm.v89i3.5631.

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