Inherited Thrombophilia in Women with Poor APL-related Obstetric History: Prevalence and Outcomes. Survey of 208 cases from the European Registry on Obstetric Antiphospholipid Syndrome Cohort
Overview
Reproductive Medicine
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Aim: To analyse the prevalence and effects of inherited thrombophilic disorders (ITD) on maternal-foetal outcomes in cases of antiphospholipid antibody related to obstetric complications.
Methods: Women with obstetric complaints who tested positive for aPL and with inherited thrombophilia were prospectively and retrospectively included.
Results: ITD data were available in 208 of 338: 147 had obstetric antiphospholipid syndrome (OAPS) and 61 aPL-related obstetric morbidity (OMAPS). 24.1% had ITD. Laboratory categories I and IIa were more related to OAPS-ITD and IIb and IIc to OMAPS-ITD. No significant differences in obstetric complaints were observed. Regarding ITD carriers, treatment rates were higher in OAPS than in OMAPS for LMWH and LDA plus LMWH (P=.002).
Conclusion: Cases with aPL-related OAPS/OMAPS showed no differences in maternal-foetal outcomes regardless of the presence of one ITD. Maternal thrombotic risk was low, with ITD-positive cases included. Registry data concur with Sydney criteria, whereby aPL-ITD-positive patients are classified as having antiphospholipid syndrome.
Camacho Saez B, Martinez-Taboada V, Merino A, Comins-Boo A, Gonzalez-Mesones B, Del Barrio-Longarela S Biomedicines. 2024; 12(6).
PMID: 38927381 PMC: 11201097. DOI: 10.3390/biomedicines12061174.
Risk factors of first thrombosis in obstetric antiphospholipid syndrome.
Luo L, Cai Q, Liu X, Hou Y, Li C Lupus Sci Med. 2024; 11(1).
PMID: 38176700 PMC: 10773425. DOI: 10.1136/lupus-2023-001044.