Nephroprotective Effect of the Leaves of (Aloe Vera) Against Toxicity Induced by Diclofenac Sodium in Albino Rabbits

Overview

Journal West Indian Med J

Specialty General Medicine

Date 2016 Jul 12

PMID 27398602

Citations 11

Authors

A Iftkhar

I J Hasan

M Sarfraz

L Jafri

M A Ashraf

Affiliations

Soon will be listed here.

Abstract

Background: The present study was designed to evaluate the nephroprotective effect of the leaves of against toxicity induced by diclofenac sodium in albino rabbits.

Subjects And Method: Thirty-six healthy albino rabbits were randomly divided into six groups each with six animals. Group 1 served as the untreated control, group 2 was treated only with diclofenac sodium, group 3 with the nephroprotective drug silymarin and groups 4, 5, and 6 were treated with different doses of 200 mg/kg, 400 mg/kg and 600 mg/kg, respectively after being treated with diclofenac sodium. Blood samples were collected after every five days up to fifteen days. Haematological and histopathological parameters were determined by using diagnostic kits.

Results: Results of haematological studies showed that use of the powder of normalized the level of different factors , white blood cells (WBCs), red blood cells (RBCs), platelet count, packed cell volume (PCV), mean cell volume (MCV) and haemoglobin (Hb) values. Histopathological studies showed that ameliorated pyknotic nuclei in the renal epithelial cells and reduced oxidative stress by increasing the level of catalase and decreasing malondialdehyde (MDA) level.

Conclusion: These results have shown that can normalize oxidative stress and can be used as an effective nephroprotective agent against drug-induced nephrotoxicity.

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