Sleep Duration and White Matter Quality in Middle-Aged Adults

Overview

Journal Sleep

Publisher Oxford University Press

Specialty Psychiatry

Date 2016 Jul 12

PMID 27397561

Citations 47

Authors

Kristine Yaffe

Ilya Nasrallah

Tina D Hoang

Diane S Lauderdale

Kristen L Knutson

Mercedes R Carnethon

Lenore J Launer

Cora E Lewis

Stephen Sidney

Affiliations

Soon will be listed here.

Abstract

Study Objectives: Sleep duration has been associated with risk of dementia and stroke, but few studies have investigated the relationship between sleep duration and brain MRI measures, particularly in middle age.

Methods: In a prospective cohort of 613 black and white adults (mean age = 45.4 years) enrolled in the Coronary Artery Risk Development in Young Adults (CARDIA) study, participants reported typical sleep duration, dichotomized into moderate sleep duration (> 6 to ≤ 8 h) and short sleep duration (≤ 6 h) at baseline (2005-2006). Five years later, we obtained brain MRI markers of white matter including fractional anisotropy, mean diffusivity, and white matter hyperintensities.

Results: Compared to moderate sleepers, short sleepers had an elevated ratio of white matter hyperintensities to normal tissue in the parietal region (OR = 2.31, 95% CI: 1.47, 3.61) adjusted for age, race/sex, education, hypertension, stroke/TIA, depression, smoking status, and physical activity. White matter diffusivity was also higher, approximately a 0.2 standard deviation difference, in frontal, parietal, and temporal white matter regions, among those reporting shorter sleep duration in (P < 0.05 for all).

Conclusions: Short sleep duration was associated with worse markers of white matter integrity in midlife. These mid-life differences in white matter may underlie the link between poor sleep and risk of dementia and stroke.

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References

Shen D, Davatzikos C . HAMMER: hierarchical attribute matching mechanism for elastic registration. IEEE Trans Med Imaging. 2003; 21(11):1421-39. DOI: 10.1109/TMI.2002.803111. View

Vernooij M, Ikram M, Vrooman H, Wielopolski P, Krestin G, Hofman A . White matter microstructural integrity and cognitive function in a general elderly population. Arch Gen Psychiatry. 2009; 66(5):545-53. DOI: 10.1001/archgenpsychiatry.2009.5. View

Zeestraten E, Benjamin P, Lambert C, Lawrence A, Williams O, Morris R . Application of Diffusion Tensor Imaging Parameters to Detect Change in Longitudinal Studies in Cerebral Small Vessel Disease. PLoS One. 2016; 11(1):e0147836. PMC: 4726604. DOI: 10.1371/journal.pone.0147836. View

Quan S, Howard B, Iber C, Kiley J, Nieto F, OConnor G . The Sleep Heart Health Study: design, rationale, and methods. Sleep. 1998; 20(12):1077-85. View

Auriel E, Edlow B, Reijmer Y, Fotiadis P, Ramirez-Martinez S, Ni J . Microinfarct disruption of white matter structure: a longitudinal diffusion tensor analysis. Neurology. 2014; 83(2):182-8. PMC: 4117171. DOI: 10.1212/WNL.0000000000000579. View

Ge B, Guo X . Short and long sleep durations are both associated with increased risk of stroke: a meta-analysis of observational studies. Int J Stroke. 2014; 10(2):177-84. DOI: 10.1111/ijs.12398. View

Lo J, Loh K, Zheng H, Sim S, Chee M . Sleep duration and age-related changes in brain structure and cognitive performance. Sleep. 2014; 37(7):1171-8. PMC: 4098802. DOI: 10.5665/sleep.3832. View

Basner M, Rao H, Goel N, Dinges D . Sleep deprivation and neurobehavioral dynamics. Curr Opin Neurobiol. 2013; 23(5):854-63. PMC: 3700596. DOI: 10.1016/j.conb.2013.02.008. View

Ramos A, Dong C, Rundek T, Elkind M, Boden-Albala B, Sacco R . Sleep duration is associated with white matter hyperintensity volume in older adults: the Northern Manhattan Study. J Sleep Res. 2014; 23(5):524-30. PMC: 4177451. DOI: 10.1111/jsr.12177. View

10.

Rosenberg S, Ryan J, Prifitera A . Rey Auditory-Verbal Learning Test performance of patients with and without memory impairment. J Clin Psychol. 1984; 40(3):785-7. DOI: 10.1002/1097-4679(198405)40:3<785::aid-jclp2270400325>3.0.co;2-4. View

11.

Lauderdale D, Knutson K, Yan L, Rathouz P, Hulley S, Sidney S . Objectively measured sleep characteristics among early-middle-aged adults: the CARDIA study. Am J Epidemiol. 2006; 164(1):5-16. DOI: 10.1093/aje/kwj199. View

12.

Hirshkowitz M, Whiton K, Albert S, Alessi C, Bruni O, DonCarlos L . National Sleep Foundation's sleep time duration recommendations: methodology and results summary. Sleep Health. 2017; 1(1):40-43. DOI: 10.1016/j.sleh.2014.12.010. View

13.

Lao Z, Shen D, Liu D, Jawad A, Melhem E, Launer L . Computer-assisted segmentation of white matter lesions in 3D MR images using support vector machine. Acad Radiol. 2008; 15(3):300-13. PMC: 2528894. DOI: 10.1016/j.acra.2007.10.012. View

14.

Bellesi M, Pfister-Genskow M, Maret S, Keles S, Tononi G, Cirelli C . Effects of sleep and wake on oligodendrocytes and their precursors. J Neurosci. 2013; 33(36):14288-300. PMC: 3874087. DOI: 10.1523/JNEUROSCI.5102-12.2013. View

15.

Macleod C . Half a century of research on the Stroop effect: an integrative review. Psychol Bull. 1991; 109(2):163-203. DOI: 10.1037/0033-2909.109.2.163. View

16.

Le Bihan D, Mangin J, Poupon C, Clark C, Pappata S, Molko N . Diffusion tensor imaging: concepts and applications. J Magn Reson Imaging. 2001; 13(4):534-46. DOI: 10.1002/jmri.1076. View

17.

Zacharaki E, Kanterakis S, Bryan R, Davatzikos C . Measuring brain lesion progression with a supervised tissue classification system. Med Image Comput Comput Assist Interv. 2008; 11(Pt 1):620-7. DOI: 10.1007/978-3-540-85988-8_74. View

18.

Gildner T, Liebert M, Kowal P, Chatterji S, Josh Snodgrass J . Associations between sleep duration, sleep quality, and cognitive test performance among older adults from six middle income countries: results from the Study on Global Ageing and Adult Health (SAGE). J Clin Sleep Med. 2014; 10(6):613-21. PMC: 4031401. DOI: 10.5664/jcsm.3782. View

19.

Devore E, Grodstein F, Schernhammer E . Sleep Duration in Relation to Cognitive Function among Older Adults: A Systematic Review of Observational Studies. Neuroepidemiology. 2016; 46(1):57-78. DOI: 10.1159/000442418. View

20.

Charlton R, Barrick T, McIntyre D, Shen Y, OSullivan M, Howe F . White matter damage on diffusion tensor imaging correlates with age-related cognitive decline. Neurology. 2006; 66(2):217-22. DOI: 10.1212/01.wnl.0000194256.15247.83. View