Expression of a Large Family of POU-domain Regulatory Genes in Mammalian Brain Development

Overview

Journal Nature

Specialty Science

Date 1989 Jul 6

PMID 2739723

Citations 213

Authors

X He

M N Treacy

D M SIMMONS

H A Ingraham

L W Swanson

M G Rosenfeld

Affiliations

Soon will be listed here.

Abstract

A novel region referred to as the POU-domain is present in two tissue-specific transcription factors, Pit-1 and Oct-2, that activate expression of genes specifying pituitary and lymphocyte phenotypes. We report the identification of multiple new members of a large family of POU-domain genes expressed in adult brain, and document that all the known mammalian POU-domain genes, including Pit-1 and Oct-2, are expressed widely in the developing nervous system.

Citing Articles

POU3F4 up-regulates Gli1 expression and promotes neuronal differentiation and synaptic development of hippocampal neural stem cells.

Zhang L, Wang J, Xu N, Guo J, Lin Y, Zhang X Stem Cell Res Ther. 2024; 15(1):440.

PMID: 39563384 PMC: 11577835. DOI: 10.1186/s13287-024-04043-1.

The Role of the Transcriptional Coactivator BOB.1/OBF.1 in Adaptive Immunity.

Betzler A, Brunner C Adv Exp Med Biol. 2024; 1459:53-77.

PMID: 39017839 DOI: 10.1007/978-3-031-62731-6_3.

A spatial-temporal map of glutamatergic neurogenesis in the murine embryonic cerebellar nuclei uncovers a high degree of cellular heterogeneity.

Casoni F, Croci L, Marroni F, Demenego G, Marullo C, Cremona O J Anat. 2024; 245(4):560-571.

PMID: 38970393 PMC: 11424815. DOI: 10.1111/joa.14107.

Clinical and Molecular Aspects Associated with Defects in the Transcription Factor POU3F4: A Review.

Bernardinelli E, Huber F, Roesch S, Dossena S Biomedicines. 2023; 11(6).

PMID: 37371790 PMC: 10296620. DOI: 10.3390/biomedicines11061695.

Implications of Transglutaminase-Mediated Protein Serotonylation in the Epigenetic Landscape, Small Cell Lung Cancer, and Beyond.

Lin J, Wu S Cancers (Basel). 2023; 15(4).

PMID: 36831672 PMC: 9954789. DOI: 10.3390/cancers15041332.