Arterial Ischemic Stroke in HIV: Defining and Classifying Etiology for Research Studies

Overview

Journal Neurol Neuroimmunol Neuroinflamm

Specialty Neurology

Date 2016 Jul 8

PMID 27386505

Citations 24

Authors

Laura A Benjamin

Alan Bryer

Sebastian Lucas

Alan Stanley

Theresa J Allain

Elizabeth Joekes

Hedley Emsley

Ian Turnbull

Colin Downey

Cheng-Hock Toh

Kevin Brown

David Brown

Catherine Ison

Colin Smith

Elizabeth L Corbett

Avindra Nath

Robert S Heyderman

Myles D Connor

Tom Solomon

Affiliations

Soon will be listed here.

Abstract

HIV infection, and potentially its treatment, increases the risk of an arterial ischemic stroke. Multiple etiologies and lack of clear case definitions inhibit progress in this field. Several etiologies, many treatable, are relevant to HIV-related stroke. To fully understand the mechanisms and the terminology used, a robust classification algorithm to help ascribe the various etiologies is needed. This consensus paper considers the strengths and limitations of current case definitions in the context of HIV infection. The case definitions for the major etiologies in HIV-related strokes were refined (e.g., varicella zoster vasculopathy and antiphospholipid syndrome) and in some instances new case definitions were described (e.g., HIV-associated vasculopathy). These case definitions provided a framework for an algorithm to help assign a final diagnosis, and help classify the subtypes of HIV etiology in ischemic stroke.

Citing Articles

Cardioembolic stroke in an HIV endemic region: underdiagnosed and severe.

Sadiq E, Woodiwiss A, Norton G, Modi G BMJ Neurol Open. 2024; 6(2):e000592.

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Herpes zoster associated with stroke incidence in people living with human immunodeficiency virus: a nested case-control study.

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