Efficiency and Outcome of Non-invasive Versus Invasive Positive Pressure Ventilation Therapy in Respiratory Failure Due to Chronic Obstructive Pulmonary Disease
Overview
Affiliations
Background: Application noninvasive ventilation in the patients with exacerbation of chronic obstructive pulmonary disease (COPD) reduced mortality. This case-control study was designed to compare efficiency and outcome of non-invasive (NIV) versus invasive positive pressure ventilation (IPPV) in respiratory failure due to COPD.
Methods: The patients were assigned to NIV or IPPV intermittantly.The clinical parameters, including RR (respiratory rate), BP (blood pressure), HR (heart rate) and PH, PaCO2, PaO2 before and 1, 4 and 24 h after treatment were measured. Demographic information such as age, sex, severity of disease based on APACHE score, length of stay and outcome were recorded.
Results: Fifty patients were enrolled in the NIV group and 50 patients in IPPV. The mean age was 70.5 in NIV and 63.9 in invasive ventilation group (p>0.05). In IPPV group, the average values of PH: PCO2: and PO2, were 7.22±0.11, 69.64 + 24.25: and 68.86±24.41 .In NIV, the respective values were 7.30±0.07, 83.94±18.95, and 60.60±19.88. In NIV group, after 1, 4 and 24 h treatment, the clinical and ventilation parameters were stable. The mean APACHE score in was IPPV, 26.46±5.45 and in NIV was 12.26±5.54 (p<0.05). The average length of hospital stay in IPPV was 15.90±10 and in NIV 8.12±6.49 days (p<0.05). The total mortality in the NIV was 4 (8%) and in IPPV, 27 patients (54%) (p<0.05).
Conclusion: This study indicates that using NIPPV is a useful therapeutic mode of treatment for respiratory failure with acceptable success rate and lower mortality. The application of NIPPV reduces hospital stay, intubation and its consequent complications.
Gudelli M, K S, Kalathil P, Pimple O, Shahid A, Chandradas N Cureus. 2024; 16(6):e62746.
PMID: 39036269 PMC: 11259907. DOI: 10.7759/cureus.62746.
Wang J, Bian S, Tang X, Ye S, Meng S, Lei W Eur J Med Res. 2021; 26(1):136.
PMID: 34861893 PMC: 8641230. DOI: 10.1186/s40001-021-00615-6.
Sohal A, Anand A, Kaur P, Kaur H, Attri J Anesth Essays Res. 2021; 15(1):8-13.
PMID: 34667341 PMC: 8462414. DOI: 10.4103/aer.aer_53_21.
Completeness of the operating room to intensive care unit handover: a matter of time?.
Dusse F, Putz J, Bohmer A, Schieren M, Joppich R, Wappler F BMC Anesthesiol. 2021; 21(1):38.
PMID: 33546588 PMC: 7863365. DOI: 10.1186/s12871-021-01247-3.
Li P, Han J, Zhang D, Cao S, Su C Exp Ther Med. 2020; 19(2):1219-1224.
PMID: 32010292 PMC: 6966231. DOI: 10.3892/etm.2019.8341.