Regulation of Stress Responses and Translational Control by Coronavirus

Overview

Journal Viruses

Publisher MDPI

Specialty Microbiology

Date 2016 Jul 8

PMID 27384577

Citations 49

Authors

To Sing Fung

Ying Liao

Ding Xiang Liu

Affiliations

Soon will be listed here.

Abstract

Similar to other viruses, coronavirus infection triggers cellular stress responses in infected host cells. The close association of coronavirus replication with the endoplasmic reticulum (ER) results in the ER stress responses, which impose a challenge to the viruses. Viruses, in turn, have come up with various mechanisms to block or subvert these responses. One of the ER stress responses is inhibition of the global protein synthesis to reduce the amount of unfolded proteins inside the ER lumen. Viruses have evolved the capacity to overcome the protein translation shutoff to ensure viral protein production. Here, we review the strategies exploited by coronavirus to modulate cellular stress response pathways. The involvement of coronavirus-induced stress responses and translational control in viral pathogenesis will also be briefly discussed.

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