Hyperglycemia Induces Cellular Hypoxia Through Production of Mitochondrial ROS Followed by Suppression of Aquaporin-1

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2016 Jul 8

PMID 27383386

Citations 48

Authors

Kiminori Sada

Takeshi Nishikawa

Daisuke Kukidome

Tomoaki Yoshinaga

Nobuhiro Kajihara

Kazuhiro Sonoda

Takafumi Senokuchi

Hiroyuki Motoshima

Takeshi Matsumura

Eiichi Araki

Affiliations

Soon will be listed here.

Abstract

We previously proposed that hyperglycemia-induced mitochondrial reactive oxygen species (mtROS) generation is a key event in the development of diabetic complications. Interestingly, some common aspects exist between hyperglycemia and hypoxia-induced phenomena. Thus, hyperglycemia may induce cellular hypoxia, and this phenomenon may also be involved in the pathogenesis of diabetic complications. In endothelial cells (ECs), cellular hypoxia increased after incubation with high glucose (HG). A similar phenomenon was observed in glomeruli of diabetic mice. HG-induced cellular hypoxia was suppressed by mitochondria blockades or manganese superoxide dismutase (MnSOD) overexpression, which is a specific SOD for mtROS. Overexpression of MnSOD also increased the expression of aquaporin-1 (AQP1), a water and oxygen channel. AQP1 overexpression in ECs suppressed hyperglycemia-induced cellular hypoxia, endothelin-1 and fibronectin overproduction, and apoptosis. Therefore, hyperglycemia-induced cellular hypoxia and mtROS generation may promote hyperglycemic damage in a coordinated manner.

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