Corticosteroid Treatment Impact on Spinal Deformity in Duchenne Muscular Dystrophy

Overview

Journal Int Sch Res Notices

Specialty Biology

Date 2016 Jul 7

PMID 27382620

Citations 3

Authors

Ilaria Sanzarello

Luciano Merlini

Francesco Traina

Michele Attilio Rosa

Cesare Faldini

Affiliations

Soon will be listed here.

Abstract

Duchenne muscular dystrophy is a progressive disease with loss of ambulation at around 9-10 years of age, followed, if untreated, by development of scoliosis, respiratory insufficiency, and death in the second decade of life. This review highlights the natural history of the disease, in particular, with regard to the development of the spinal deformity and how this complication has been modified by surgical interventions and overall by corticosteroid treatment. The beneficial effect of corticosteroids may have also an impact on the clinical trial design of the new emerging causative therapies.

Citing Articles

The Efficacy of Naïve versus Modified Mesenchymal Stem Cells in Improving Muscle Function in Duchenne Muscular Dystrophy: A Systematic Review.

Shen O, Chen Y, Xu H, Lee C Biomedicines. 2021; 9(9).

PMID: 34572283 PMC: 8467288. DOI: 10.3390/biomedicines9091097.

Current management of Duchenne muscular dystrophy in the Middle East: expert report.

Al Jumah M, Muhaizea M, Al Rumayyan A, Al Saman A, Al Shehri A, Cupler E Neurodegener Dis Manag. 2019; 9(3):123-133.

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Improving clinical trial design for Duchenne muscular dystrophy.

Merlini L, Sabatelli P BMC Neurol. 2015; 15:153.

PMID: 26306629 PMC: 4549867. DOI: 10.1186/s12883-015-0408-z.

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