A Rare Balanced Nonrobertsonian Translocation Involving Acrocentric Chromosomes: Chromosome Abnormality of T(13;15)(p11.2;q22.1)

Overview

Journal J Hum Reprod Sci

Date 2016 Jul 7

PMID 27382241

Citations 2

Authors

Dalvi Rupa

Koppaka Neeraja

Chavan Deepak

Mandava Swarna

Affiliations

Soon will be listed here.

Abstract

Background: Balanced non-robertsonian translocation (RT), involving acrocentric chromosomes, is a rare event and only a few cases are reported. Most of the RTs are balanced involving acrocentric chromosomes with the breakpoints (q10;q10).

Materials And Methods: Chromosome analysis was performed as per standard procedure - Giemsa-trypsin banding with 500 band resolution was analyzed for chromosome identification.

Results: In the present study, we report a rare balanced non-RTs involving chromosomes 13 and 15 with cytogenetic finding of 46, XX, t(13;15) (p11.2;q22.1).

Conclusion: To the best of our knowledge, this is the first such report of an unusual non-RT of t(13:15) with (p11.2;q22.1) break points.

Citing Articles

Prenatal Diagnosis of a New Case: Balanced Non-Robertsonian Translocation Involving t(15;22)(p11.2;q11.2).

Ei A, H G, E A, H T, Gf V, C I Balkan J Med Genet. 2019; 21(2):69-72.

PMID: 30984529 PMC: 6454237. DOI: 10.2478/bjmg-2018-0020.

The Survey of Double Robertsonian Translocation 13q; 14q in the Pedigree of 44; XX Woman: A Case Report.

Malekpour N, Kormi S, Azadbakht M, Yousefi M, Hasanzadeh-Nazar Abadi M Int J Mol Cell Med. 2018; 6(4):243-248.

PMID: 29988217 PMC: 6004290. DOI: 10.22088/BUMS.6.4.243.

References

Mangelschots K, Van Roy B, Speleman F, van Roy N, Gheuens J, Beuten J . Reciprocal translocation between the proximal regions of the long arms of chromosomes 13 and 15 resulting in unbalanced offspring: characterization by fluorescence in situ hybridization and DNA analysis. Hum Genet. 1992; 89(4):407-13. DOI: 10.1007/BF00194312. View

Wirth J, Wagner T, Meyer J, Pfeiffer R, TIETZE H, Schempp W . Translocation breakpoints in three patients with campomelic dysplasia and autosomal sex reversal map more than 130 kb from SOX9. Hum Genet. 1996; 97(2):186-93. DOI: 10.1007/BF02265263. View

Cramer D, Wise L . The epidemiology of recurrent pregnancy loss. Semin Reprod Med. 2001; 18(4):331-9. DOI: 10.1055/s-2000-13722. View

Moorhead P, Nowell P, Mellman W, BATTIPS D, HUNGERFORD D . Chromosome preparations of leukocytes cultured from human peripheral blood. Exp Cell Res. 1960; 20:613-6. DOI: 10.1016/0014-4827(60)90138-5. View

Nielsen J, Wohlert M . Chromosome abnormalities found among 34,910 newborn children: results from a 13-year incidence study in Arhus, Denmark. Hum Genet. 1991; 87(1):81-3. DOI: 10.1007/BF01213097. View