Age-related Changes in the Brain Antioxidant Status: Modulation by Dietary Supplementation of Decalepis Hamiltonii and Physical Exercise

Overview

Journal Mol Cell Biochem

Publisher Springer

Specialty Biochemistry

Date 2016 Jul 6

PMID 27379504

Citations 3

Authors

Tekupalli Ravikiran

Ramachandregowda Sowbhagya

Sindhghatta Kariyappa Anupama

Santosh Anand

Dundaiah Bhagyalakshmi

Affiliations

Soon will be listed here.

Abstract

The synergistic effects of physical exercise and diet have profound benefits on brain function. The present study was aimed to determine the effects of exercise and Decalepis hamiltonii (Dh) on age-related responses on the antioxidant status in discrete regions of rat brain. Male Wistar albino rats of 4 and 18 months old were orally supplemented with Dh extract and swim trained at 3 % intensity for 30 min/day, 5 days/week, for a period of 30 days. Supplementation of 100 mg Dh aqueous extract/kg body weight and its combination with exercise significantly elevated the antioxidant enzyme activities irrespective of age. Age-related and region-specific changes were observed in superoxide levels, and protein carbonyl and malondialdehyde contents, and were found to be decreased in both trained and supplemented groups. Levels of total thiols, protein, and nonprotein thiols decreased with age and significantly increased in the SW-T(+100 mg) groups. Our results demonstrated that the interactive effects of two treatments enhanced the antioxidant status and decreased the risk of protein and lipid oxidation in the rat brain.

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