Biomimetic Scaffold with Aligned Microporosity Designed for Dentin Regeneration

Overview

Journal Front Bioeng Biotechnol

Date 2016 Jul 5

PMID 27376060

Citations 12

Authors

Silvia Panseri

Monica Montesi

Samuele Maria Dozio

Elisa Savini

Anna Tampieri

Monica Sandri

Affiliations

Soon will be listed here.

Abstract

Tooth loss is a common result of a variety of oral diseases due to physiological causes, trauma, genetic disorders, and aging and can lead to physical and mental suffering that markedly lowers the individual's quality of life. Tooth is a complex organ that is composed of mineralized tissues and soft connective tissues. Dentin is the most voluminous tissue of the tooth and its formation (dentinogenesis) is a highly regulated process displaying several similarities with osteogenesis. In this study, gelatin, thermally denatured collagen, was used as a promising low-cost material to develop scaffolds for hard tissue engineering. We synthetized dentin-like scaffolds using gelatin biomineralized with magnesium-doped hydroxyapatite and blended it with alginate. With a controlled freeze-drying process and alginate cross-linking, it is possible to obtain scaffolds with microscopic aligned channels suitable for tissue engineering. 3D cell culture with mesenchymal stem cells showed the promising properties of the new scaffolds for tooth regeneration. In detail, the chemical-physical features of the scaffolds, mimicking those of natural tissue, facilitate the cell adhesion, and the porosity is suitable for long-term cell colonization and fine cell-material interactions.

Citing Articles

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Enhancing bone formation using absorbable AZ31B magnesium alloy membranes during distraction osteogenesis: A new material study.

Zhao G, Wang S, Wang G, Zhang B, Huang H, Yao Y Heliyon. 2023; 9(8):e18032.

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The potential of eggshell hydroxyapatite, collagen, and EGCG (HAp-Col-EGCG) scaffold as a pulp regeneration material.

Elline E, Ismiyatin K, Budhy T, Bhardwaj A Saudi Dent J. 2022; 34(8):715-722.

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Additive-Free Gelatine-Based Devices for Chondral Tissue Regeneration: Shaping Process Comparison among Mould Casting and Three-Dimensional Printing.

Montanari M, Sangiorgi A, Campodoni E, Bassi G, Gardini D, Montesi M Polymers (Basel). 2022; 14(5).

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Materials for Dentoalveolar Bioprinting: Current State of the Art.

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