Nutritional Aspects of Treatment in Epileptic Patients

Overview

Journal Iran J Child Neurol

Specialty Pediatrics

Date 2016 Jul 5

PMID 27375750

Citations 5

Authors

Danesh Soltani

Majid Ghaffar Pour

Abbas Tafakhori

Payam Sarraf

Sama Bitarafan

Affiliations

Soon will be listed here.

Abstract

Epilepsy is a neurological disorder characterized by interruption of normal neuronal functions that is manifested by behavioral disorders, changing of awareness level, and presence of some sensory, autonomic and motor symptoms or signs. It is resulted from many different causes. Many antiepileptic drugs (AEDs) are considered to manage epileptic attacks. Some of them change metabolism and absorption of many nutrients. Therefore, epileptic patients may be in higher risk of nutrient deficiency and its unwelcome effects. In the present paper, we intend to review the relationship between nutrition and epilepsy in two aspects. In one aspect we discuss the nutritional status in epileptic patients, the causes of nutritional deficiencies and the way of compensation of the nutrient deficiencies. It will guide these patients to have a healthy life. In another aspect we explain the role of some nutrients and specific diets in management of epileptic attacks. It can help to better control of epileptic attacks in these patients.

Citing Articles

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References

Dahlin M, Hjelte L, Nilsson S, Amark P . Plasma phospholipid fatty acids are influenced by a ketogenic diet enriched with n-3 fatty acids in children with epilepsy. Epilepsy Res. 2006; 73(2):199-207. DOI: 10.1016/j.eplepsyres.2006.10.005. View

Ahmad B, Hill K, OBrien T, Gorelik A, Habib N, Wark J . Falls and fractures in patients chronically treated with antiepileptic drugs. Neurology. 2012; 79(2):145-51. DOI: 10.1212/WNL.0b013e31825f0466. View

Hartman A, Gasior M, Vining E, Rogawski M . The neuropharmacology of the ketogenic diet. Pediatr Neurol. 2007; 36(5):281-92. PMC: 1940242. DOI: 10.1016/j.pediatrneurol.2007.02.008. View

Liu C, Wu H, Kao S, Wei Y . Serum trace elements, glutathione, copper/zinc superoxide dismutase, and lipid peroxidation in epileptic patients with phenytoin or carbamazepine monotherapy. Clin Neuropharmacol. 1998; 21(1):62-4. View

Ullah I, Badshah H, Naseer M, Lee H, Kim M . Thymoquinone and vitamin C attenuates pentylenetetrazole-induced seizures via activation of GABAB1 receptor in adult rats cortex and hippocampus. Neuromolecular Med. 2014; 17(1):35-46. DOI: 10.1007/s12017-014-8337-3. View

Fitzpatrick L . Pathophysiology of bone loss in patients receiving anticonvulsant therapy. Epilepsy Behav. 2004; 5 Suppl 2:S3-15. DOI: 10.1016/j.yebeh.2003.11.026. View

Leo M, Lowe N, Lieber C . Decreased hepatic vitamin A after drug administration in men and in rats. Am J Clin Nutr. 1984; 40(6):1131-6. DOI: 10.1093/ajcn/40.6.1131. View

Danial N, Hartman A, Stafstrom C, Thio L . How does the ketogenic diet work? Four potential mechanisms. J Child Neurol. 2013; 28(8):1027-33. PMC: 3971996. DOI: 10.1177/0883073813487598. View

Poduri A, Sheidley B, Shostak S, Ottman R . Genetic testing in the epilepsies-developments and dilemmas. Nat Rev Neurol. 2014; 10(5):293-9. PMC: 4090104. DOI: 10.1038/nrneurol.2014.60. View

10.

Brodie M, Mintzer S, Pack A, Gidal B, Vecht C, Schmidt D . Enzyme induction with antiepileptic drugs: cause for concern?. Epilepsia. 2012; 54(1):11-27. DOI: 10.1111/j.1528-1167.2012.03671.x. View

11.

Speed D, OBrien T, Palotie A, Shkura K, Marson A, Balding D . Describing the genetic architecture of epilepsy through heritability analysis. Brain. 2014; 137(Pt 10):2680-9. PMC: 4163034. DOI: 10.1093/brain/awu206. View

12.

Ebert D, Haller R, Walton M . Energy contribution of octanoate to intact rat brain metabolism measured by 13C nuclear magnetic resonance spectroscopy. J Neurosci. 2003; 23(13):5928-35. PMC: 6741266. View

13.

McGarry J, Foster D . The regulation of ketogenesis from octanoic acid. The role of the tricarboxylic acid cycle and fatty acid synthesis. J Biol Chem. 1971; 246(4):1149-59. View

14.

Gillman M, Sandyk R . Nicotinic acid deficiency induced by sodium valproate. S Afr Med J. 1984; 65(25):986. View

15.

Ray K . Epilepsy: antiepileptic drugs reduce vitamin B(12) and folate levels. Nat Rev Neurol. 2011; 7(3):125. DOI: 10.1038/nrneurol.2011.9. View

16.

Kovac S, Abramov A, Walker M . Energy depletion in seizures: anaplerosis as a strategy for future therapies. Neuropharmacology. 2012; 69:96-104. DOI: 10.1016/j.neuropharm.2012.05.012. View

17.

DeGiorgio C, Miller P, Harper R, Gornbein J, Schrader L, Soss J . Fish oil (n-3 fatty acids) in drug resistant epilepsy: a randomised placebo-controlled crossover study. J Neurol Neurosurg Psychiatry. 2014; 86(1):65-70. DOI: 10.1136/jnnp-2014-307749. View

18.

Mintzer S, Skidmore C, Sperling M . B-vitamin deficiency in patients treated with antiepileptic drugs. Epilepsy Behav. 2012; 24(3):341-4. DOI: 10.1016/j.yebeh.2012.04.132. View

19.

Petty S, OBrien T, Wark J . Anti-epileptic medication and bone health. Osteoporos Int. 2006; 18(2):129-42. DOI: 10.1007/s00198-006-0185-z. View

20.

Wlaz P, Socala K, Nieoczym D, Zarnowski T, Zarnowska I, Czuczwar S . Acute anticonvulsant effects of capric acid in seizure tests in mice. Prog Neuropsychopharmacol Biol Psychiatry. 2014; 57:110-6. DOI: 10.1016/j.pnpbp.2014.10.013. View