Modulating Dickkopf-1: A Strategy to Monitor or Treat Cancer?

Overview

Journal Cancers (Basel)

Publisher MDPI

Specialty Oncology

Date 2016 Jul 2

PMID 27367730

Citations 17

Authors

Melody Mazon

Delphine Masi

Madeleine Carreau

Affiliations

Soon will be listed here.

Abstract

Dickkopf-1 (DKK1) is a secreted Wnt/β-catenin pathway antagonist involved in embryogenesis. It was first described 25 years ago for its function in head induction and limb morphogenesis. Since then, this protein has been widely studied in the context of active Wnt/β-catenin signalling during cellular differentiation and development. Dysregulation of DKK1 has been associated with bone pathologies and has now emerged as a potential biomarker of cancer progression and prognosis for several types of malignancies. Reducing the amount of circulating DKK1 may reveal a simple and efficient strategy to limit or reverse cancer growth. This review will provide an overview of the role of Dickkopf-1 in cancer and explore its potential use as a biomarker and therapeutic target.

Citing Articles

Dickkopf-1 promotes tumor progression of gefitinib- resistant non-small cell lung cancer through cancer cell-fibroblast interactions.

Choi M, Choi Y, Lee Y, Lee Y, Chung J, Kang K Exp Hematol Oncol. 2025; 14(1):24.

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DKK1 and Its Receptors in Esophageal Adenocarcinoma: A Promising Molecular Target.

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Prognostic value of cancer-associated fibroblasts-related genes in lung adenocarcinoma.

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Characterization of the Immune Infiltration Landscape and Identification of Prognostic Biomarkers for Esophageal Cancer.

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Drug Discovery of DKK1 Inhibitors.

Jiang H, Zhang Z, Yu Y, Chu H, Yu S, Yao S Front Pharmacol. 2022; 13:847387.

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