Vesicle-MaNiA: Extracellular Vesicles in Liquid Biopsy and Cancer

Overview

Journal Curr Opin Pharmacol

Specialty Pharmacology

Date 2016 Jul 2

PMID 27366992

Citations 36

Authors

Veronica Torrano

Felix Royo

Hector Peinado

Ana Loizaga-Iriarte

Miguel Unda

Juan M Falcon-Perez

Arkaitz Carracedo

Affiliations

Soon will be listed here.

Abstract

Normal and tumor cells shed vesicles to the environment. Within the large family of extracellular vesicles, exosomes and microvesicles have attracted much attention in the recent years. Their interest ranges from mediators of cancer progression, inflammation, immune regulation and metastatic niche regulation, to non-invasive biomarkers of disease. In this respect, the procedures to purify and analyze extracellular vesicles have quickly evolved and represent a source of variability for data integration in the field. In this review, we provide an updated view of the potential of exosomes and microvesicles as biomarkers and the available technologies for their isolation.

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