Visit-to-visit Variation of Fasting Plasma Glucose is a Predictor of Hip Fracture in Older Persons with Type 2 Diabetes: the Taiwan Diabetes Study

Overview

Journal Osteoporos Int

Specialties Endocrinology
Orthopedics

Date 2016 Jul 2

PMID 27363401

Citations 8

Authors

J I-H Chiang

T-C Li

C-I Li

C-S Liu

N-H Meng

W-Y Lin

S-Y Yang

H-J Chen

C-C Lin

Affiliations

Soon will be listed here.

Abstract

Introduction: Hip fracture is a major health burden in the population and is associated with high rates of mortality and morbidity especially in elderly. It is evident that diabetes mellitus is a risk factor of osteoporosis which is a significant risk factor of hip fracture. However, epidemiological studies exploring the risks of hip fracture among type 2 diabetic patients are limited.

Methods: A retrospective study of 26,501 ethnic Chinese older persons enrolled in the National Diabetes Care Management program in Taiwan was conducted; related factors were analyzed with extended Cox proportional hazards regression models to competing risk data on hip fracture incidence.

Results: The results show a temporal association between FPG-CV and hip fracture as patients categorized as FPG-CV greater than 25.4 % showed an increased risk in hip fractures, confirming a linear relationship between the two. After multivariate adjustment, the risk of hip fracture increased among patients with FPG-CV of 25.4-42.3 % and >42.3 % compared with patients with FPG-CV of ≦ 14.3 % (hazard ratio, 1.35; 95 % confidence interval 1.14-1.60 and 1.27; 1.07-1.52, respectively). Significant linear trends among various FPG-CV were observed.

Conclusions: Thus, the present study demonstrated the importance of glucose stability for fracture prevention in older persons with type 2 diabetes. Future studies should be conducted to explore whether reduction in glucose oscillation in older adults with diabetes mellitus can reduce the risk of hip fracture.

Citing Articles

Correlation Between Blood Glucose Fluctuations and Osteoporosis in Type 2 Diabetes Mellitus.

Chen F, Wang P, Dai F, Zhang Q, Ying R, Ai L Int J Endocrinol. 2025; 2025:8889420.

PMID: 39949568 PMC: 11824305. DOI: 10.1155/ije/8889420.

The impact of fasting plasma glucose variability on osteoporotic fractures.

Liu R, Gao L, Guo L, Xu W, Wu S, Tian D Front Endocrinol (Lausanne). 2023; 14:1187682.

PMID: 37455924 PMC: 10348823. DOI: 10.3389/fendo.2023.1187682.

The use of metformin, sulfonylurea compounds and insulin and the risk of hip fractures in diabetic patients: a systematic review and meta-analysis of observational studies.

Bahardoust M, Yarali M, Donyadideh G, Rahimi E, Naderi D, Tehrani F BMC Musculoskelet Disord. 2023; 24(1):367.

PMID: 37161384 PMC: 10170842. DOI: 10.1186/s12891-023-06493-9.

Association between trajectories of fasting plasma glucose and risk of osteoporosis in non-diabetic and diabetic populations.

Wang P, Zhang Y, Shan R, Wu J, Man S, Deng Y Front Public Health. 2022; 10:960928.

PMID: 36424968 PMC: 9679646. DOI: 10.3389/fpubh.2022.960928.

Efficacy of bisphosphonate therapy on postmenopausal osteoporotic women with and without diabetes: a prospective trial.

Kim J, Kim K, Lim S, Kang M, Baek K, Min Y BMC Endocr Disord. 2022; 22(1):99.

PMID: 35410197 PMC: 9004203. DOI: 10.1186/s12902-022-01010-w.

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