» Articles » PMID: 27362506

Prenatal DHA Supplementation and Infant Attention

Overview
Journal Pediatr Res
Specialties Biology
Pediatrics
Date 2016 Jul 1
PMID 27362506
Citations 26
Authors
Affiliations
Soon will be listed here.
Abstract

Background: Results of randomized trials on the effects of prenatal docosahexaenoic acid (DHA) on infant cognition are mixed, but most trials have used global standardized outcomes, which may not be sensitive to effects of DHA on specific cognitive domains.

Methods: Women were randomized to 600 mg/d DHA or a placebo for the last two trimesters of pregnancy. Infants of these mothers were then followed on tests of visual habituation at 4, 6, and 9 mo of age.

Results: DHA supplementation did not affect look duration or habituation parameters but infants of supplemented mothers maintained high levels of sustained attention (SA) across the first year; SA declined for the placebo group. The supplemented group also showed significantly reduced attrition on habituation tasks, especially at 6 and 9 mo.

Conclusion: The findings support with the suggestion that prenatal DHA may positively affect infants' attention and regulation of state.

Citing Articles

Adaptive changes in multiple aspects of emotion regulation in the offspring of pregnant persons receiving a diet-and-exercise intervention relative to usual pregnancy care: a randomized controlled trial.

Krzeczkowski J, Mortaji N, Atkinson S, Schmidt L, Van Lieshout R Am J Clin Nutr. 2024; 121(1):50-59.

PMID: 39486684 PMC: 11747193. DOI: 10.1016/j.ajcnut.2024.10.022.


Docosahexaenoic Acid (DHA) and Eicosapentaenoic Acid (EPA)-Should They Be Mandatory Supplements in Pregnancy?.

Amza M, Haj Hamoud B, Sima R, Dinu M, Gorecki G, Popescu M Biomedicines. 2024; 12(7).

PMID: 39062044 PMC: 11274850. DOI: 10.3390/biomedicines12071471.


Infant formula supplemented with milk fat globule membrane compared with standard infant formula for the cognitive development of healthy term-born formula-fed infants: protocol for a randomised controlled trial.

Gould J, Gibson R, Yelland L, Colombo J, McPhee A, Gallier S BMJ Open. 2024; 14(6):e083399.

PMID: 38951000 PMC: 11331355. DOI: 10.1136/bmjopen-2023-083399.


Could early life DHA supplementation benefit neurodevelopment? A systematic review and meta-analysis.

Hu R, Xu J, Hua Y, Li Y, Li J Front Neurol. 2024; 15:1295788.

PMID: 38645744 PMC: 11032049. DOI: 10.3389/fneur.2024.1295788.


External Disruption of Ocular Development .

Kim H, Sarrafpour S, Teng C, Liu J Yale J Biol Med. 2024; 97(1):41-48.

PMID: 38559457 PMC: 10964818. DOI: 10.59249/RRMM8911.


References
1.
Gustafson K, Carlson S, Colombo J, Yeh H, Shaddy D, Li S . Effects of docosahexaenoic acid supplementation during pregnancy on fetal heart rate and variability: a randomized clinical trial. Prostaglandins Leukot Essent Fatty Acids. 2013; 88(5):331-8. PMC: 3734850. DOI: 10.1016/j.plefa.2013.01.009. View

2.
Richards J . The development of sustained visual attention in infants from 14 to 26 weeks of age. Psychophysiology. 1985; 22(4):409-16. DOI: 10.1111/j.1469-8986.1985.tb01625.x. View

3.
Jensen C, Voigt R, Llorente A, Peters S, Prager T, Zou Y . Effects of early maternal docosahexaenoic acid intake on neuropsychological status and visual acuity at five years of age of breast-fed term infants. J Pediatr. 2010; 157(6):900-5. DOI: 10.1016/j.jpeds.2010.06.006. View

4.
Makrides M, Duley L, Olsen S . Marine oil, and other prostaglandin precursor, supplementation for pregnancy uncomplicated by pre-eclampsia or intrauterine growth restriction. Cochrane Database Syst Rev. 2006; (3):CD003402. DOI: 10.1002/14651858.CD003402.pub2. View

5.
Carlson S, Colombo J, Gajewski B, Gustafson K, Mundy D, Yeast J . DHA supplementation and pregnancy outcomes. Am J Clin Nutr. 2013; 97(4):808-15. PMC: 3607655. DOI: 10.3945/ajcn.112.050021. View