The Impact of Concomitant Left Ventricular Non-compaction with Congenital Heart Disease on Perioperative Outcomes

Overview

Journal Pediatr Cardiol

Specialties Cardiology & Vascular Diseases
Pediatrics

Date 2016 Jul 1

PMID 27357002

Citations 9

Authors

Preeti Ramachandran

Jessica G Woo

Thomas D Ryan

Roosevelt Bryant

Haleh C Heydarian

John L Jefferies

Jeffrey A Towbin

Angela Lorts

Affiliations

Soon will be listed here.

Abstract

Left ventricular non-compaction (LVNC) is a heterogeneous myocardial disorder characterized by prominent trabeculations and inter-trabecular recesses which may occur in association with congenital heart disease (CHD). To date, few studies have been performed to assess whether the concomitant diagnosis of LVNC affects the outcomes of CHD surgery. A retrospective review of patients with LVNC with CHD (LVNC-CHD), 0-5 years of age, was conducted. Patients with CHD without LVNC (CHD-only) and 0-5 years of age with similar diagnosis distribution were selected for comparison. Perioperative data, including CHD diagnosis, operative course, and postoperative complications were collected and compared between groups. LVNC-CHD was diagnosed in 26 children. Of the 26 with LVNC-CHD, 20 underwent surgery and these patients were compared with 276 CHD-only controls. Median total length of stay in the hospital was 12.5 days (IQR 5.5-63 days) in LVNC-CHD compared to 5 days (IQR 3-10 days) in CHD-only (p < 0.005). Postoperative death, cardiac arrest, or need for ECMO or transplantation occurred in 6/20 (30 %) of the LVNC-CHD patients compared to 3/276 (1 %) of the CHD-only group (p < 0.0001). LVNC-CHD patients had significantly longer hospital length of stay and higher perioperative complications compared to CHD-only patients without myocardial abnormalities. Pediatric cardiac care teams should be cognizant of the possibility of the increased perioperative risk associated with concomitant LVNC. Future prospective studies are warranted.

Citing Articles

Left Ventricular Non-Compaction: Evolving Concepts.

Pittorru R, De Lazzari M, Migliore F, Frasson E, Zorzi A, Cipriani A J Clin Med. 2024; 13(19).

PMID: 39407735 PMC: 11477328. DOI: 10.3390/jcm13195674.

Left Ventricular Noncompaction-A Systematic Review of Risk Factors in the Pediatric Population.

Luczak-Wozniak K, Werner B J Clin Med. 2021; 10(6).

PMID: 33809657 PMC: 8001197. DOI: 10.3390/jcm10061232.

Genetics and Clinical Features of Noncompaction Cardiomyopathy in the Fetal Population.

Sun H, Hao X, Wang X, Zhou X, Zhang Y, Liu X Front Cardiovasc Med. 2021; 7:617561.

PMID: 33553264 PMC: 7854697. DOI: 10.3389/fcvm.2020.617561.

Left Ventricular Noncompaction Is More Prevalent in Ventricular Septal Defect Than Other Congenital Heart Defects: A Morphological Study.

Marques L, Liguori G, Souza A, Aiello V J Cardiovasc Dev Dis. 2020; 7(4).

PMID: 32992881 PMC: 7711793. DOI: 10.3390/jcdd7040039.

Neonatal Non-compacted Cardiomyopathy: Predictors of Poor Outcome.

Rodriguez-Fanjul J, Tubio-Gomez S, Carretero Bellon J, Bautista-Rodriguez C, Sanchez-de-Toledo J Pediatr Cardiol. 2019; 41(1):175-180.

PMID: 31758211 DOI: 10.1007/s00246-019-02241-w.

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