Gender-related Differences in Food Craving and Obesity

Overview

Journal Yale J Biol Med

Specialty Biology

Date 2016 Jun 30

PMID 27354843

Citations 55

Authors

Jessica Hallam

Rebecca G Boswell

Elise E DeVito

Hedy Kober

Affiliations

Soon will be listed here.

Abstract

Food craving is often defined as a strong desire to eat. Much work has shown that it consistently and prospectively predicts eating and weight-related outcomes, contributing to the growing obesity epidemic. Although there are clear gender differences in the prevalence and health consequences of obesity, relatively little recent work has investigated gender differences in craving, or any sex-hormone-based differences as they relate to phases of the menstrual cycle. Here, we propose that gender-related differences in food craving contribute to gender-related differences in obesity. Drawing on findings in the addiction literature, we highlight ways to incorporate gender-based differences in food craving into treatment approaches, potentially improving the efficacy of obesity and weight loss treatment. Overall, this review aims to emphasize the importance of investigating gender differences in food craving, with a view towards informing the development of more effective treatments for obesity and weight loss.

Citing Articles

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References

Anderson J, Greenway F, Fujioka K, Gadde K, McKenney J, ONeil P . Bupropion SR enhances weight loss: a 48-week double-blind, placebo- controlled trial. Obes Res. 2002; 10(7):633-41. DOI: 10.1038/oby.2002.86. View

Litt M, Cooney N, Morse P . Reactivity to alcohol-related stimuli in the laboratory and in the field: predictors of craving in treated alcoholics. Addiction. 2000; 95(6):889-900. DOI: 10.1046/j.1360-0443.2000.9568896.x. View

Epstein D, Marrone G, Heishman S, Schmittner J, Preston K . Tobacco, cocaine, and heroin: Craving and use during daily life. Addict Behav. 2009; 35(4):318-24. PMC: 2849634. DOI: 10.1016/j.addbeh.2009.11.003. View

Wang G, Volkow N, Telang F, Jayne M, Ma Y, Pradhan K . Evidence of gender differences in the ability to inhibit brain activation elicited by food stimulation. Proc Natl Acad Sci U S A. 2009; 106(4):1249-54. PMC: 2633545. DOI: 10.1073/pnas.0807423106. View

Chase H, Eickhoff S, Laird A, Hogarth L . The neural basis of drug stimulus processing and craving: an activation likelihood estimation meta-analysis. Biol Psychiatry. 2011; 70(8):785-793. PMC: 4827617. DOI: 10.1016/j.biopsych.2011.05.025. View

Smith D, Robbins T . The neurobiological underpinnings of obesity and binge eating: a rationale for adopting the food addiction model. Biol Psychiatry. 2012; 73(9):804-10. DOI: 10.1016/j.biopsych.2012.08.026. View

Gale E, Gillespie K . Diabetes and gender. Diabetologia. 2001; 44(1):3-15. DOI: 10.1007/s001250051573. View

Scott K, McGee M, Wells J, Oakley Browne M . Obesity and mental disorders in the adult general population. J Psychosom Res. 2007; 64(1):97-105. DOI: 10.1016/j.jpsychores.2007.09.006. View

Harris J, Pomeranz J, Lobstein T, Brownell K . A crisis in the marketplace: how food marketing contributes to childhood obesity and what can be done. Annu Rev Public Health. 2008; 30:211-25. DOI: 10.1146/annurev.publhealth.031308.100304. View

10.

Dye L, Warner P, Bancroft J . Food craving during the menstrual cycle and its relationship to stress, happiness of relationship and depression; a preliminary enquiry. J Affect Disord. 1995; 34(3):157-64. DOI: 10.1016/0165-0327(95)00013-d. View

11.

Demos K, Heatherton T, Kelley W . Individual differences in nucleus accumbens activity to food and sexual images predict weight gain and sexual behavior. J Neurosci. 2012; 32(16):5549-52. PMC: 3377379. DOI: 10.1523/JNEUROSCI.5958-11.2012. View

12.

DeVito E, Herman A, Waters A, Valentine G, Sofuoglu M . Subjective, physiological, and cognitive responses to intravenous nicotine: effects of sex and menstrual cycle phase. Neuropsychopharmacology. 2013; 39(6):1431-40. PMC: 3988546. DOI: 10.1038/npp.2013.339. View

13.

Haber S, Knutson B . The reward circuit: linking primate anatomy and human imaging. Neuropsychopharmacology. 2009; 35(1):4-26. PMC: 3055449. DOI: 10.1038/npp.2009.129. View

14.

Hay P . A systematic review of evidence for psychological treatments in eating disorders: 2005-2012. Int J Eat Disord. 2013; 46(5):462-9. DOI: 10.1002/eat.22103. View

15.

Volkow N, Wang G, Fowler J, Telang F . Overlapping neuronal circuits in addiction and obesity: evidence of systems pathology. Philos Trans R Soc Lond B Biol Sci. 2008; 363(1507):3191-200. PMC: 2607335. DOI: 10.1098/rstb.2008.0107. View

16.

Hill D, Craighead L, Safer D . Appetite-focused dialectical behavior therapy for the treatment of binge eating with purging: a preliminary trial. Int J Eat Disord. 2010; 44(3):249-61. DOI: 10.1002/eat.20812. View

17.

Cushing C, Benoit S, Peugh J, Reiter-Purtill J, Inge T, Zeller M . Longitudinal trends in hedonic hunger after Roux-en-Y gastric bypass in adolescents. Surg Obes Relat Dis. 2013; 10(1):125-30. PMC: 4420196. DOI: 10.1016/j.soard.2013.05.009. View

18.

Greenway F, Fujioka K, Plodkowski R, Mudaliar S, Guttadauria M, Erickson J . Effect of naltrexone plus bupropion on weight loss in overweight and obese adults (COR-I): a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial. Lancet. 2010; 376(9741):595-605. DOI: 10.1016/S0140-6736(10)60888-4. View

19.

Everitt B, Belin D, Economidou D, Pelloux Y, Dalley J, Robbins T . Review. Neural mechanisms underlying the vulnerability to develop compulsive drug-seeking habits and addiction. Philos Trans R Soc Lond B Biol Sci. 2008; 363(1507):3125-35. PMC: 2607322. DOI: 10.1098/rstb.2008.0089. View

20.

Kober H, Mende-Siedlecki P, Kross E, Weber J, Mischel W, Hart C . Prefrontal-striatal pathway underlies cognitive regulation of craving. Proc Natl Acad Sci U S A. 2010; 107(33):14811-6. PMC: 2930456. DOI: 10.1073/pnas.1007779107. View