Meta-analysis of Risk Factors Associated with Atherosclerosis in Patients with Kawasaki Disease

Overview

Journal World J Pediatr

Specialty Pediatrics

Date 2016 Jun 29

PMID 27351565

Citations 6

Authors

Han Zhang

Ming-Guo Xu

Li-Jian Xie

Min Huang

Jie Shen

Ting-Ting Xiao

Affiliations

Soon will be listed here.

Abstract

Background: Kawasaki disease (KD) has now become the leading cause of acquired heart disease among children in developed countries. This study investigated whether patients with KD have an increased risk of atherosclerosis.

Methods: Electronic databases, including PubMed, Embase and Springer link, were searched through June 1, 2015, for eligible studies. Studies were included when they met the following criteria: 1) an observational study focusing on evaluating the risk factors for atherosclerosis in patients with KD; 2) KD was diagnosed clinically according to the Japan Kawasaki Disease Research Committee or American Heart Association's diagnostic criteria; 3) the study subjects were KD patients without coronary heart disease or related cardiovascular disease (KD group) and non-KD patients as control (control group), and 4) investigation of important atherosclerosis risk factors, total cholesterol (TC), low-density lipoprotein cholesterol (LDL), triglycerides (TG), systolic blood pressure (SBP), and flowmediated dilatation (FMD). The methodological quality of the included studies was evaluated using the Newcastle- Ottawa Scale. Mean difference (MD) and relative risk (RR) and corresponding 95% confidence intervals (CI) were used to calculate the pooled results.

Results: Sixteen studies were included with a total of 870 patients, including 421 KD patients and 449 non-KD controls. Differences in TG and SBP between KD patients and controls were not significant; in contrast, TC and LDL levels were significantly higher in KD patients than the controls, whereas FMD in the KD patients was significantly lower.

Conclusions: KD patients may have an increased risk of developing atherosclerosis.

Citing Articles

Assessment of Endothelial Dysfunction in Patients with Kawasaki Disease: A Meta-Analysis.

Yu X, Wu D, Song G Rev Cardiovasc Med. 2024; 23(8):260.

PMID: 39076622 PMC: 11266953. DOI: 10.31083/j.rcm2308260.

Kawasaki Disease: Pathology, Risks, and Management.

Seki M, Minami T Vasc Health Risk Manag. 2022; 18:407-416.

PMID: 35711626 PMC: 9196282. DOI: 10.2147/VHRM.S291762.

Diagnostic Value of Immune-Related Genes in Kawasaki Disease.

Liu D, Song M, Jing F, Liu B, Yi Q Front Genet. 2021; 12:763496.

PMID: 34956318 PMC: 8709561. DOI: 10.3389/fgene.2021.763496.

An Update on Cardiovascular Risk Factors After Kawasaki Disease.

Zeng Y, Zhang M, Ko S, Chen F Front Cardiovasc Med. 2021; 8:671198.

PMID: 33937365 PMC: 8086797. DOI: 10.3389/fcvm.2021.671198.

Oxidised Low-Density Lipoprotein and Its Receptor-Mediated Endothelial Dysfunction Are Associated with Coronary Artery Lesions in Kawasaki Disease.

He Y, Qiu H, Wu R, Rong X, Xu H, Xiang R J Cardiovasc Transl Res. 2019; 13(2):204-214.

PMID: 31428922 DOI: 10.1007/s12265-019-09908-y.

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