Triterpenes in Cancer: Significance and Their Influence

Overview

Journal Mol Biol Rep

Specialty Molecular Biology

Date 2016 Jun 27

PMID 27344437

Citations 23

Authors

Balraj Singh Gill

Sanjeev Kumar

Navgeet

Affiliations

Soon will be listed here.

Abstract

Natural products are enriched with numerous compounds with a broad spectrum of therapeutics indication suggesting the role of functional moieties as a core pharmacophore. This review highlights the role of triterpene in targeting signaling pathways in cancer. Advancement in cellular, biochemical, experimental, and computational approaches provides new insights into various pathways in cancer. In signaling network, triterpenes primarily target membrane receptors which control and modulates expression level of the biological responses. Triterpenes are immunomodulatory targeting nuclear factor kappa B, toll-like receptors, signal transducer and activator of transcription 3, and PI3K/Akt/mTOR. Triterpenes isolated from plants and fungus mainly focus on the process of apoptosis while other signaling areas in the cancer are still shrouded. Some of the triterpenes have already passed the clinical trial, whereas many more have been proven to yield effective results. This review would help the researchers to study the role of triterpenes in cancer, thus, helping them to discover and design efficacious therapeutics agents.

Citing Articles

A review on ethnobotany, phytochemistry, and pharmacology of the genus DC.

Shu L, Li K, Yang S, Hu M, Ming X, Yan B Front Pharmacol. 2024; 15:1479963.

PMID: 39619617 PMC: 11604426. DOI: 10.3389/fphar.2024.1479963.

An Update on Pentacyclic Triterpenoids Ursolic and Oleanolic Acids and Related Derivatives as Anticancer Candidates.

Similie D, Minda D, Bora L, Kroskins V, Luginina J, Turks M Antioxidants (Basel). 2024; 13(8).

PMID: 39199198 PMC: 11351203. DOI: 10.3390/antiox13080952.

Biological Properties of Oleanolic Acid Derivatives Bearing Functionalized Side Chains at C-3.

Fontana G, Badalamenti N, Bruno M, Maggi F, DellAnnunziata F, Capuano N Int J Mol Sci. 2024; 25(15).

PMID: 39126048 PMC: 11312724. DOI: 10.3390/ijms25158480.

Chaga mushroom triterpenoids as adjuncts to minimally invasive cancer therapies: A review.

Plehn S, Wagle S, Rupasinghe H Curr Res Toxicol. 2023; 5:100137.

PMID: 38046279 PMC: 10692653. DOI: 10.1016/j.crtox.2023.100137.

Rubiarbonol B induces RIPK1-dependent necroptosis via NOX1-derived ROS production.

Byun H, Ju E, Park K, Sohn K, Jung C, Hong J Cell Biol Toxicol. 2022; 39(4):1677-1696.

PMID: 36163569 DOI: 10.1007/s10565-022-09774-6.

References

Yang P, Yang C, Huang C, Hsu K . Phosphatidylinositol 3-kinase activation is required for stress protocol-induced modification of hippocampal synaptic plasticity. J Biol Chem. 2007; 283(5):2631-43. DOI: 10.1074/jbc.M706954200. View

Wang Y, Lv Y, Lu L, Cai L . Oridonin inhibits mTOR signaling and the growth of lung cancer tumors. Anticancer Drugs. 2014; 25(10):1192-200. DOI: 10.1097/CAD.0000000000000154. View

Schlessinger J . Cell signaling by receptor tyrosine kinases. Cell. 2000; 103(2):211-25. DOI: 10.1016/s0092-8674(00)00114-8. View

Martin R, Ibeas E, Carvalho-Tavares J, Hernandez M, Ruiz-Gutierrez V, Nieto M . Natural triterpenic diols promote apoptosis in astrocytoma cells through ROS-mediated mitochondrial depolarization and JNK activation. PLoS One. 2009; 4(6):e5975. PMC: 2695006. DOI: 10.1371/journal.pone.0005975. View

Lemmon M, Schlessinger J . Cell signaling by receptor tyrosine kinases. Cell. 2010; 141(7):1117-34. PMC: 2914105. DOI: 10.1016/j.cell.2010.06.011. View

Gill B, Alex J, Navgeet , Kumar S . Missing link between microRNA and prostate cancer. Tumour Biol. 2016; 37(5):5683-704. DOI: 10.1007/s13277-016-4900-x. View

Astrinidis A, Henske E . Tuberous sclerosis complex: linking growth and energy signaling pathways with human disease. Oncogene. 2005; 24(50):7475-81. DOI: 10.1038/sj.onc.1209090. View

Negi A, Ramarao P, Kumar R . Recent advancements in small molecule inhibitors of insulin-like growth factor-1 receptor (IGF-1R) tyrosine kinase as anticancer agents. Mini Rev Med Chem. 2013; 13(5):653-81. DOI: 10.2174/1389557511313050004. View

Yadav V, Prasad S, Sung B, Kannappan R, Aggarwal B . Targeting inflammatory pathways by triterpenoids for prevention and treatment of cancer. Toxins (Basel). 2011; 2(10):2428-66. PMC: 3153165. DOI: 10.3390/toxins2102428. View

10.

DeGraffenried L, Friedrichs W, Russell D, Donzis E, Middleton A, Silva J . Inhibition of mTOR activity restores tamoxifen response in breast cancer cells with aberrant Akt Activity. Clin Cancer Res. 2004; 10(23):8059-67. DOI: 10.1158/1078-0432.CCR-04-0035. View

11.

Beuvink I, Boulay A, Fumagalli S, Zilbermann F, Ruetz S, OReilly T . The mTOR inhibitor RAD001 sensitizes tumor cells to DNA-damaged induced apoptosis through inhibition of p21 translation. Cell. 2005; 120(6):747-59. DOI: 10.1016/j.cell.2004.12.040. View

12.

Ruggero D, Pandolfi P . Does the ribosome translate cancer?. Nat Rev Cancer. 2003; 3(3):179-92. DOI: 10.1038/nrc1015. View

13.

Jiang J, Slivova V, Harvey K, Valachovicova T, Sliva D . Ganoderma lucidum suppresses growth of breast cancer cells through the inhibition of Akt/NF-kappaB signaling. Nutr Cancer. 2004; 49(2):209-16. DOI: 10.1207/s15327914nc4902_13. View

14.

Hay N, Sonenberg N . Upstream and downstream of mTOR. Genes Dev. 2004; 18(16):1926-45. DOI: 10.1101/gad.1212704. View

15.

Liby K, Yore M, Sporn M . Triterpenoids and rexinoids as multifunctional agents for the prevention and treatment of cancer. Nat Rev Cancer. 2007; 7(5):357-69. DOI: 10.1038/nrc2129. View

16.

Folkman J . Angiogenesis in cancer, vascular, rheumatoid and other disease. Nat Med. 1995; 1(1):27-31. DOI: 10.1038/nm0195-27. View

17.

Schneider P, Thome M, Burns K, Bodmer J, Hofmann K, Kataoka T . TRAIL receptors 1 (DR4) and 2 (DR5) signal FADD-dependent apoptosis and activate NF-kappaB. Immunity. 1998; 7(6):831-6. DOI: 10.1016/s1074-7613(00)80401-x. View

18.

Liu J . Studies of the molecular mechanisms in the regulation of telomerase activity. FASEB J. 1999; 13(15):2091-104. DOI: 10.1096/fasebj.13.15.2091. View

19.

OKANO J, Gaslightwala I, Birnbaum M, Rustgi A, Nakagawa H . Akt/protein kinase B isoforms are differentially regulated by epidermal growth factor stimulation. J Biol Chem. 2000; 275(40):30934-42. DOI: 10.1074/jbc.M004112200. View

20.

Alghasham A . Cucurbitacins - a promising target for cancer therapy. Int J Health Sci (Qassim). 2013; 7(1):77-89. PMC: 3612419. DOI: 10.12816/0006025. View