Loss of Alleles from the Distal Short Arm of Chromosome 1 Occurs Late in Melanoma Tumor Progression

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 1989 Jun 1

PMID 2734311

Citations 31

Authors

N C Dracopoli

P Harnett

S J Bale

B Z Stanger

M A Tucker

D E Housman

R F Kefford

Affiliations

Soon will be listed here.

Abstract

The gene for familial malignant melanoma and its precursor lesion, the dysplastic nevus, has been assigned to a region of the distal short arm of chromosome 1, which is frequently involved in karyotypic abnormalities in melanoma cells. We have examined loci on chromosome 1p for loss-of-constitutional heterozygosity in 35 melanomas and 21 melanoma cell lines to analyze the role of these abnormalities in melanocyte transformation. Loss-of-heterozygosity at loci on chromosome 1p was identified in 15/35 (43%) melanomas and 11/21 (52%) melanoma cell lines. Analysis of multiple metastases derived from the same patient and of melanoma and lymphoblastoid samples from a family with hereditary melanoma showed that the loss-of-heterozygosity at loci on distal 1p is a late event in tumor progression, rather than the second mutation that would occur if melanoma were due to a cellular recessive mechanism. Comparisons with neuroblastoma and multiple endocrine neoplasia (MEN2) suggest that the frequent 1p loss-of-heterozygosity in these malignancies is a common late event of neuroectodermal tumor progression.

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