Brain Activation Differences in Schizophrenia During Context-dependent Processing of Saccade Tasks

Overview

Journal Behav Brain Funct

Publisher Biomed Central

Specialties Neurology
Psychology
Social Sciences

Date 2016 Jun 26

PMID 27342314

Citations 4

Authors

A L Rodrigue

B P Austin

K A Dyckman

J E McDowell

Affiliations

Soon will be listed here.

Abstract

Background: Brain function in schizophrenia has been probed using saccade paradigms and functional magnetic resonance imaging, but little information exists about how changing task context impacts saccade related brain activation and behavioral performance. We recruited schizophrenia and comparison subjects to perform saccade tasks in differing contexts: (1) two single task runs (anti- or pro-saccades alternating with fixation) and (2) one dual task run (antisaccades alternating with prosaccades).

Results: Context-dependent differences in saccade circuitry were evaluated using ROI analyses. Distinction between anti- and pro-saccade activation across contexts (single versus dual task) suggests that the schizophrenia group did not respond to context in the same way as the comparison group.

Conclusions: Further investigation of context processing effects on brain activation and saccade performance measures informs models of cognitive deficits in the disorder and enhances understanding of antisaccades as a potential endophenotype for schizophrenia.

Citing Articles

Positive and Negative Symptoms Are Associated with Distinct Effects on Predictive Saccades.

Smith E, Crawford T Brain Sci. 2022; 12(4).

PMID: 35447950 PMC: 9025332. DOI: 10.3390/brainsci12040418.

Saccadic eye movements in different dimensions of schizophrenia and in clinical high-risk state for psychosis.

Obyedkov I, Skuhareuskaya M, Skugarevsky O, Obyedkov V, Buslauski P, Skuhareuskaya T BMC Psychiatry. 2019; 19(1):110.

PMID: 30961571 PMC: 6454611. DOI: 10.1186/s12888-019-2093-8.

Regularized aggregation of statistical parametric maps.

Wang L, Chung J, Park C, Choi H, Rodrigue A, Pierce J Hum Brain Mapp. 2018; 40(1):65-79.

PMID: 30184306 PMC: 6865509. DOI: 10.1002/hbm.24355.

Failure to mobilize cognitive control for challenging tasks correlates with symptom severity in schizophrenia.

Baran B, Karahanoglu F, Agam Y, Mantonakis L, Manoach D Neuroimage Clin. 2016; 12:887-893.

PMID: 27872811 PMC: 5109850. DOI: 10.1016/j.nicl.2016.10.020.

References

Camchong J, Dyckman K, Austin B, Clementz B, McDowell J . Common neural circuitry supporting volitional saccades and its disruption in schizophrenia patients and relatives. Biol Psychiatry. 2008; 64(12):1042-50. PMC: 3339629. DOI: 10.1016/j.biopsych.2008.06.015. View

McDowell J, Brown G, Paulus M, Martinez A, Stewart S, Dubowitz D . Neural correlates of refixation saccades and antisaccades in normal and schizophrenia subjects. Biol Psychiatry. 2002; 51(3):216-23. DOI: 10.1016/s0006-3223(01)01204-5. View

Jenkinson M, Beckmann C, Behrens T, Woolrich M, Smith S . FSL. Neuroimage. 2011; 62(2):782-90. DOI: 10.1016/j.neuroimage.2011.09.015. View

McDowell J, Dyckman K, Austin B, Clementz B . Neurophysiology and neuroanatomy of reflexive and volitional saccades: evidence from studies of humans. Brain Cogn. 2008; 68(3):255-70. PMC: 2614688. DOI: 10.1016/j.bandc.2008.08.016. View

Stratta P, Daneluzzo E, Bustini M, Prosperini P, Rossi A . Processing of context information in schizophrenia: relation to clinical symptoms and WCST performance. Schizophr Res. 2000; 44(1):57-67. DOI: 10.1016/s0920-9964(99)00142-5. View

Greenzang C, Manoach D, Goff D, Barton J . Task-switching in schizophrenia: active switching costs and passive carry-over effects in an antisaccade paradigm. Exp Brain Res. 2007; 181(3):493-502. DOI: 10.1007/s00221-007-0946-8. View

Rosano C, Krisky C, Welling J, Eddy W, Luna B, Thulborn K . Pursuit and saccadic eye movement subregions in human frontal eye field: a high-resolution fMRI investigation. Cereb Cortex. 2001; 12(2):107-15. DOI: 10.1093/cercor/12.2.107. View

Levine J, Meiran N, Henik A . Task set switching in schizophrenia. Neuropsychology. 2000; 14(3):471-82. DOI: 10.1037//0894-4105.14.3.471. View

MacDonald 3rd A, Carter C, Kerns J, Ursu S, Barch D, Holmes A . Specificity of prefrontal dysfunction and context processing deficits to schizophrenia in never-medicated patients with first-episode psychosis. Am J Psychiatry. 2005; 162(3):475-84. DOI: 10.1176/appi.ajp.162.3.475. View

10.

Barbalat G, Chambon V, Franck N, Koechlin E, Farrer C . Organization of cognitive control within the lateral prefrontal cortex in schizophrenia. Arch Gen Psychiatry. 2009; 66(4):377-86. DOI: 10.1001/archgenpsychiatry.2009.10. View

11.

Kieffaber P, ODonnell B, Shekhar A, Hetrick W . Event related brain potential evidence for preserved attentional set switching in schizophrenia. Schizophr Res. 2007; 93(1-3):355-65. PMC: 2062485. DOI: 10.1016/j.schres.2007.03.018. View

12.

Servan-Schreiber D, Cohen J, Steingard S . Schizophrenic deficits in the processing of context. A test of a theoretical model. Arch Gen Psychiatry. 1996; 53(12):1105-12. DOI: 10.1001/archpsyc.1996.01830120037008. View

13.

Barch D, Carter C, MacDonald 3rd A, Braver T, Cohen J . Context-processing deficits in schizophrenia: diagnostic specificity, 4-week course, and relationships to clinical symptoms. J Abnorm Psychol. 2003; 112(1):132-43. View

14.

Cohen J, Barch D, Carter C, Servan-Schreiber D . Context-processing deficits in schizophrenia: converging evidence from three theoretically motivated cognitive tasks. J Abnorm Psychol. 1999; 108(1):120-33. DOI: 10.1037//0021-843x.108.1.120. View

15.

Franke C, Reuter B, Schulz L, Kathmann N . Schizophrenia patients show impaired response switching in saccade tasks. Biol Psychol. 2007; 76(1-2):91-9. DOI: 10.1016/j.biopsycho.2007.06.006. View

16.

Cannon T, Glahn D, Kim J, van Erp T, Karlsgodt K, Cohen M . Dorsolateral prefrontal cortex activity during maintenance and manipulation of information in working memory in patients with schizophrenia. Arch Gen Psychiatry. 2005; 62(10):1071-80. DOI: 10.1001/archpsyc.62.10.1071. View

17.

Schmithorst V, Holland S . Comparison of three methods for generating group statistical inferences from independent component analysis of functional magnetic resonance imaging data. J Magn Reson Imaging. 2004; 19(3):365-8. PMC: 2265794. DOI: 10.1002/jmri.20009. View

18.

Karch S, Leicht G, Giegling I, Lutz J, Kunz J, Buselmeier M . Inefficient neural activity in patients with schizophrenia and nonpsychotic relatives of schizophrenic patients: evidence from a working memory task. J Psychiatr Res. 2009; 43(15):1185-94. DOI: 10.1016/j.jpsychires.2009.04.004. View

19.

Tan H, Sust S, Buckholtz J, Mattay V, Meyer-Lindenberg A, Egan M . Dysfunctional prefrontal regional specialization and compensation in schizophrenia. Am J Psychiatry. 2006; 163(11):1969-77. DOI: 10.1176/ajp.2006.163.11.1969. View

20.

Breton F, Plante A, Legauffre C, Morel N, Ades J, Gorwood P . The executive control of attention differentiates patients with schizophrenia, their first-degree relatives and healthy controls. Neuropsychologia. 2010; 49(2):203-8. DOI: 10.1016/j.neuropsychologia.2010.11.019. View