Muraymycin Nucleoside-peptide Antibiotics: Uridine-derived Natural Products As Lead Structures for the Development of Novel Antibacterial Agents

Overview

Journal Beilstein J Org Chem

Specialty Chemistry

Date 2016 Jun 25

PMID 27340469

Citations 28

Authors

Daniel Wiegmann

Stefan Koppermann

Marius Wirth

Giuliana Niro

Kristin Leyerer

Christian Ducho

Affiliations

Soon will be listed here.

Abstract

Muraymycins are a promising class of antimicrobial natural products. These uridine-derived nucleoside-peptide antibiotics inhibit the bacterial membrane protein translocase I (MraY), a key enzyme in the intracellular part of peptidoglycan biosynthesis. This review describes the structures of naturally occurring muraymycins, their mode of action, synthetic access to muraymycins and their analogues, some structure-activity relationship (SAR) studies and first insights into muraymycin biosynthesis. It therefore provides an overview on the current state of research, as well as an outlook on possible future developments in this field.

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