Roles of IL-33 in Resistance and Tolerance to Systemic Candida Albicans Infections

Overview

Journal Immune Netw

Specialty Allergy & Immunology

Date 2016 Jun 25

PMID 27340384

Citations 3

Authors

Sang Jun Park

Hong Rae Cho

Byungsuk Kwon

Affiliations

Soon will be listed here.

Abstract

IL-33 is a multifunctional cytokine that is released in response to a variety of intrinsic and extrinsic stimuli. The role of IL-33 in Candida albicans infections is just beginning to be revealed. This cytokine has beneficial effects on host defense against systemic C. albicans infections, and it promotes resistance mechanisms by which the immune system eliminates the invading fungal pathogens; and it also elevates host tolerance by reducing the inflammatory response and thereby, potentially, tissue damage. Thus, IL-33 is classified as a cytokine that has evolved functionally to protect the host from damage by pathogens and immunopathology.

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References

Lionakis M . New insights into innate immune control of systemic candidiasis. Med Mycol. 2014; 52(6):555-64. PMC: 4823972. DOI: 10.1093/mmy/myu029. View

Kim J, Kim W, Moon U, Kim H, Choi H, Sin J . Intratumorally Establishing Type 2 Innate Lymphoid Cells Blocks Tumor Growth. J Immunol. 2016; 196(5):2410-23. DOI: 10.4049/jimmunol.1501730. View

Le H, Kim W, Kim J, Cho H, Kwon B . Interleukin-33: a mediator of inflammation targeting hematopoietic stem and progenitor cells and their progenies. Front Immunol. 2013; 4:104. PMC: 3644799. DOI: 10.3389/fimmu.2013.00104. View

Alves-Filho J, Sonego F, Souto F, Freitas A, Verri Jr W, Auxiliadora-Martins M . Interleukin-33 attenuates sepsis by enhancing neutrophil influx to the site of infection. Nat Med. 2010; 16(6):708-12. DOI: 10.1038/nm.2156. View

Molofsky A, Van Gool F, Liang H, Van Dyken S, Nussbaum J, Lee J . Interleukin-33 and Interferon-γ Counter-Regulate Group 2 Innate Lymphoid Cell Activation during Immune Perturbation. Immunity. 2015; 43(1):161-74. PMC: 4512852. DOI: 10.1016/j.immuni.2015.05.019. View

Moro K, Kabata H, Tanabe M, Koga S, Takeno N, Mochizuki M . Interferon and IL-27 antagonize the function of group 2 innate lymphoid cells and type 2 innate immune responses. Nat Immunol. 2015; 17(1):76-86. DOI: 10.1038/ni.3309. View

Lionakis M, Swamydas M, Fischer B, Plantinga T, Johnson M, Jaeger M . CX3CR1-dependent renal macrophage survival promotes Candida control and host survival. J Clin Invest. 2013; 123(12):5035-51. PMC: 3859390. DOI: 10.1172/JCI71307. View

Arpaia N, Green J, Moltedo B, Arvey A, Hemmers S, Yuan S . A Distinct Function of Regulatory T Cells in Tissue Protection. Cell. 2015; 162(5):1078-89. PMC: 4603556. DOI: 10.1016/j.cell.2015.08.021. View

Kolodin D, van Panhuys N, Li C, Magnuson A, Cipolletta D, Miller C . Antigen- and cytokine-driven accumulation of regulatory T cells in visceral adipose tissue of lean mice. Cell Metab. 2015; 21(4):543-57. PMC: 4747251. DOI: 10.1016/j.cmet.2015.03.005. View

10.

Kim J, Kim W, Le H, Moon U, Tran V, Kim H . IL-33-induced hematopoietic stem and progenitor cell mobilization depends upon CCR2. J Immunol. 2014; 193(7):3792-802. DOI: 10.4049/jimmunol.1400176. View

11.

Sonnenberg G, Artis D . Innate lymphoid cells in the initiation, regulation and resolution of inflammation. Nat Med. 2015; 21(7):698-708. PMC: 4869856. DOI: 10.1038/nm.3892. View

12.

Kulkarni O, Hartter I, Mulay S, Hagemann J, Darisipudi M, Kumar Vr S . Toll-like receptor 4-induced IL-22 accelerates kidney regeneration. J Am Soc Nephrol. 2014; 25(5):978-89. PMC: 4005301. DOI: 10.1681/ASN.2013050528. View

13.

Sakai N, Van Sweringen H, Quillin R, Schuster R, Blanchard J, Burns J . Interleukin-33 is hepatoprotective during liver ischemia/reperfusion in mice. Hepatology. 2012; 56(4):1468-78. PMC: 3465516. DOI: 10.1002/hep.25768. View

14.

Tran V, Kim H, Kim J, Kang S, Moon U, Cho H . IL-33 Enhances Host Tolerance to Candida albicans Kidney Infections through Induction of IL-13 Production by CD4+ T Cells. J Immunol. 2015; 194(10):4871-9. DOI: 10.4049/jimmunol.1402986. View

15.

Le H, Tran V, Kim W, Kim J, Cho H, Kwon B . IL-33 priming regulates multiple steps of the neutrophil-mediated anti-Candida albicans response by modulating TLR and dectin-1 signals. J Immunol. 2012; 189(1):287-95. DOI: 10.4049/jimmunol.1103564. View

16.

Villarreal D, Wise M, Walters J, Reuschel E, Choi M, Obeng-Adjei N . Alarmin IL-33 acts as an immunoadjuvant to enhance antigen-specific tumor immunity. Cancer Res. 2014; 74(6):1789-800. PMC: 4130175. DOI: 10.1158/0008-5472.CAN-13-2729. View

17.

Gales A, Conduche A, Bernad J, Lefevre L, Olagnier D, Beraud M . PPARγ controls Dectin-1 expression required for host antifungal defense against Candida albicans. PLoS Pathog. 2010; 6(1):e1000714. PMC: 2795865. DOI: 10.1371/journal.ppat.1000714. View

18.

Schmitz J, Owyang A, Oldham E, Song Y, Murphy E, McClanahan T . IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines. Immunity. 2005; 23(5):479-90. DOI: 10.1016/j.immuni.2005.09.015. View

19.

Medzhitov R, Schneider D, Soares M . Disease tolerance as a defense strategy. Science. 2012; 335(6071):936-41. PMC: 3564547. DOI: 10.1126/science.1214935. View

20.

Schiering C, Krausgruber T, Chomka A, Frohlich A, Adelmann K, Wohlfert E . The alarmin IL-33 promotes regulatory T-cell function in the intestine. Nature. 2014; 513(7519):564-568. PMC: 4339042. DOI: 10.1038/nature13577. View