Sub-Optimal Treatment of Bacterial Biofilms

Overview

Journal Antibiotics (Basel)

Specialty Pharmacology

Date 2016 Jun 25

PMID 27338489

Citations 26

Authors

Tianyan Song

Marylise Duperthuy

Sun Nyunt Wai

Affiliations

Soon will be listed here.

Abstract

Bacterial biofilm is an emerging clinical problem recognized in the treatment of infectious diseases within the last two decades. The appearance of microbial biofilm in clinical settings is steadily increasing due to several reasons including the increased use of quality of life-improving artificial devices. In contrast to infections caused by planktonic bacteria that respond relatively well to standard antibiotic therapy, biofilm-forming bacteria tend to cause chronic infections whereby infections persist despite seemingly adequate antibiotic therapy. This review briefly describes the responses of biofilm matrix components and biofilm-associated bacteria towards sub-lethal concentrations of antimicrobial agents, which may include the generation of genetic and phenotypic variabilities. Clinical implications of bacterial biofilms in relation to antibiotic treatments are also discussed.

Citing Articles

Antimicrobial Sub-MIC induces Staphylococcus aureus biofilm formation without affecting the bacterial count.

Elawady R, Aboulela A, Gaballah A, Ghazal A, Amer A BMC Infect Dis. 2024; 24(1):1065.

PMID: 39342123 PMC: 11438285. DOI: 10.1186/s12879-024-09790-3.

Biofilm Lifecycle: Involvement of Mechanical Constraints and Timeline of Matrix Production.

David A, Tahrioui A, Tareau A, Forge A, Gonzalez M, Bouffartigues E Antibiotics (Basel). 2024; 13(8).

PMID: 39199987 PMC: 11350761. DOI: 10.3390/antibiotics13080688.

Agar and agarose used for Staphylococcus aureus biofilm cultivation impact fluoroquinolone tolerance.

Power A, Mok W J Appl Microbiol. 2024; 135(8).

PMID: 39066496 PMC: 11301810. DOI: 10.1093/jambio/lxae191.

Subminimum Inhibitory Concentrations Tetracycline Antibiotics Induce Biofilm Formation in Minocycline-Resistant by Affecting Bacterial Physical and Chemical Properties and Associated Genes Expression.

Guo T, Yang L, Zhou N, Wang Z, Huan C, Zhou J ACS Infect Dis. 2024; 10(8):2929-2938.

PMID: 38949961 PMC: 11321339. DOI: 10.1021/acsinfecdis.4c00280.

Fighting fibrin with fibrin: Vancomycin delivery into coagulase-mediated Staphylococcus aureus biofilms via fibrin-based nanoparticle binding.

Scull G, Aligwekwe A, Rey Y, Koch D, Nellenbach K, Sheridan A J Biomed Mater Res A. 2024; 112(12):2071-2085.

PMID: 38874363 PMC: 11464197. DOI: 10.1002/jbm.a.37760.

References

Cheow W, Chang M, Hadinoto K . Antibacterial efficacy of inhalable antibiotic-encapsulated biodegradable polymeric nanoparticles against E. coli biofilm cells. J Biomed Nanotechnol. 2011; 6(4):391-403. DOI: 10.1166/jbn.2010.1116. View

Kvist M, Hancock V, Klemm P . Inactivation of efflux pumps abolishes bacterial biofilm formation. Appl Environ Microbiol. 2008; 74(23):7376-82. PMC: 2592912. DOI: 10.1128/AEM.01310-08. View

Parsek M, Greenberg E . Sociomicrobiology: the connections between quorum sensing and biofilms. Trends Microbiol. 2005; 13(1):27-33. DOI: 10.1016/j.tim.2004.11.007. View

Weissman K, Muller R . Myxobacterial secondary metabolites: bioactivities and modes-of-action. Nat Prod Rep. 2010; 27(9):1276-95. DOI: 10.1039/c001260m. View

Mathur J, Davis B, Waldor M . Antimicrobial peptides activate the Vibrio cholerae sigmaE regulon through an OmpU-dependent signalling pathway. Mol Microbiol. 2006; 63(3):848-58. DOI: 10.1111/j.1365-2958.2006.05544.x. View

Davis B, Waldor M . High-throughput sequencing reveals suppressors of Vibrio cholerae rpoE mutations: one fewer porin is enough. Nucleic Acids Res. 2009; 37(17):5757-67. PMC: 2761261. DOI: 10.1093/nar/gkp568. View

Ren C, Konstan M, Yegin A, Rasouliyan L, Trzaskoma B, Morgan W . Multiple antibiotic-resistant Pseudomonas aeruginosa and lung function decline in patients with cystic fibrosis. J Cyst Fibros. 2012; 11(4):293-9. PMC: 4089904. DOI: 10.1016/j.jcf.2012.02.005. View

Kulka K, Hatfull G, Ojha A . Growth of Mycobacterium tuberculosis biofilms. J Vis Exp. 2012; (60). PMC: 3376936. DOI: 10.3791/3820. View

Rivardo F, Martinotti M, Turner R, Ceri H . Synergistic effect of lipopeptide biosurfactant with antibiotics against Escherichia coli CFT073 biofilm. Int J Antimicrob Agents. 2011; 37(4):324-31. DOI: 10.1016/j.ijantimicag.2010.12.011. View

10.

Fux C, Quigley M, Worel A, Post C, Zimmerli S, Ehrlich G . Biofilm-related infections of cerebrospinal fluid shunts. Clin Microbiol Infect. 2006; 12(4):331-7. DOI: 10.1111/j.1469-0691.2006.01361.x. View

11.

Parsek M, Singh P . Bacterial biofilms: an emerging link to disease pathogenesis. Annu Rev Microbiol. 2003; 57:677-701. DOI: 10.1146/annurev.micro.57.030502.090720. View

12.

Doroshenko N, Tseng B, Howlin R, Deacon J, Wharton J, Thurner P . Extracellular DNA impedes the transport of vancomycin in Staphylococcus epidermidis biofilms preexposed to subinhibitory concentrations of vancomycin. Antimicrob Agents Chemother. 2014; 58(12):7273-82. PMC: 4249571. DOI: 10.1128/AAC.03132-14. View

13.

Santos A, Watanabe E, Andrade D . Biofilm on artificial pacemaker: fiction or reality?. Arq Bras Cardiol. 2011; 97(5):e113-20. DOI: 10.1590/s0066-782x2011001400018. View

14.

Barsoumian A, Mende K, Sanchez Jr C, Beckius M, Wenke J, Murray C . Clinical infectious outcomes associated with biofilm-related bacterial infections: a retrospective chart review. BMC Infect Dis. 2015; 15:223. PMC: 4458033. DOI: 10.1186/s12879-015-0972-2. View

15.

Beyth N, Houri-Haddad Y, Domb A, Khan W, Hazan R . Alternative antimicrobial approach: nano-antimicrobial materials. Evid Based Complement Alternat Med. 2015; 2015:246012. PMC: 4378595. DOI: 10.1155/2015/246012. View

16.

Costerton J, Stewart P, Greenberg E . Bacterial biofilms: a common cause of persistent infections. Science. 1999; 284(5418):1318-22. DOI: 10.1126/science.284.5418.1318. View

17.

Gerdes K, Maisonneuve E . Bacterial persistence and toxin-antitoxin loci. Annu Rev Microbiol. 2012; 66:103-23. DOI: 10.1146/annurev-micro-092611-150159. View

18.

Schadow K, Simpson W, Christensen G . Characteristics of adherence to plastic tissue culture plates of coagulase-negative staphylococci exposed to subinhibitory concentrations of antimicrobial agents. J Infect Dis. 1988; 157(1):71-7. DOI: 10.1093/infdis/157.1.71. View

19.

Waters V, Ratjen F . Standard versus biofilm antimicrobial susceptibility testing to guide antibiotic therapy in cystic fibrosis. Cochrane Database Syst Rev. 2015; (3):CD009528. DOI: 10.1002/14651858.CD009528.pub3. View

20.

Smith E, Buckley D, Wu Z, Saenphimmachak C, Hoffman L, DArgenio D . Genetic adaptation by Pseudomonas aeruginosa to the airways of cystic fibrosis patients. Proc Natl Acad Sci U S A. 2006; 103(22):8487-92. PMC: 1482519. DOI: 10.1073/pnas.0602138103. View