Multi-Elemental Profiling of Tibial and Maxillary Trabecular Bone in Ovariectomised Rats

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2016 Jun 25

PMID 27338361

Authors

Pingping Han

Shifeier Lu

Yinghong Zhou

Karine Moromizato

Zhibin Du

Thor Friis

Yin Xiao

Affiliations

Soon will be listed here.

Abstract

Atomic minerals are the smallest components of bone and the content of Ca, being the most abundant mineral in bone, correlates strongly with the risk of osteoporosis. Postmenopausal women have a far greater risk of suffering from OP due to low Ca concentrations in their bones and this is associated with low bone mass and higher bone fracture rates. However, bone strength is determined not only by Ca level, but also a number of metallic and non-metallic elements in bone. Thus, in this study, the difference of metallic and non-metallic elements in ovariectomy-induced osteoporosis tibial and maxillary trabecular bone was investigated in comparison with sham operated normal bone by laser ablation inductively-coupled plasma mass spectrometry using a rat model. The results demonstrated that the average concentrations of (25)Mg, (28)Si, (39)K, (47)Ti, (56)Fe, (59)Co, (77)Se, (88)Sr, (137)Ba, and (208)Pb were generally higher in tibia than those in maxilla. Compared with the sham group, Ovariectomy induced more significant changes of these elements in tibia than maxilla, indicating tibial trabecular bones are more sensitive to changes of circulating estrogen. In addition, the concentrations of (28)Si, (77)Se, (208)Pb, and Ca/P ratios were higher in tibia and maxilla in ovariectomised rats than those in normal bone at all time-points. The present study indicates that ovariectomy could significantly impact the element distribution and concentrations between tibia and maxilla.

References

Brito J, Costa I, Maia E Silva A, Marques J, Zagalo C, Cavaleiro I . Changes in bone Pb accumulation: cause and effect of altered bone turnover. Bone. 2014; 64:228-34. DOI: 10.1016/j.bone.2014.04.021. View

Staessen J, Buchet J, Ginucchio G, Lauwerys R, Lijnen P, Roels H . Public health implications of environmental exposure to cadmium and lead: an overview of epidemiological studies in Belgium. Working Groups. J Cardiovasc Risk. 1996; 3(1):26-41. View

Teofilo J, Azevedo A, Petenusci S, Mazaro R, Lamano-Carvalho T . Comparison between two experimental protocols to promote osteoporosis in the maxilla and proximal tibia of female rats. Pesqui Odontol Bras. 2004; 17(4):302-6. DOI: 10.1590/s1517-74912003000400002. View

Park J, Kelly B, Kenner G, von Recum A, Grether M, Coffeen W . Piezoelectric ceramic implants: in vivo results. J Biomed Mater Res. 1981; 15(1):103-10. DOI: 10.1002/jbm.820150114. View

M-M P, Weiskirchen R, Gassler N, Bosserhoff A, Sabine Becker J . Novel bioimaging techniques of metals by laser ablation inductively coupled plasma mass spectrometry for diagnosis of fibrotic and cirrhotic liver disorders. PLoS One. 2013; 8(3):e58702. PMC: 3591358. DOI: 10.1371/journal.pone.0058702. View

Pollack A, Mumford S, Wactawski-Wende J, Yeung E, Mendola P, Mattison D . Bone mineral density and blood metals in premenopausal women. Environ Res. 2012; 120:76-81. PMC: 3534953. DOI: 10.1016/j.envres.2012.06.001. View

Toti P, Sbordone C, Martuscelli R, Califano L, Ramaglia L, Sbordone L . Gene clustering analysis in human osteoporosis disease and modifications of the jawbone. Arch Oral Biol. 2013; 58(8):912-29. DOI: 10.1016/j.archoralbio.2013.02.013. View

Roth A, Lehmann G . [Histology versus measuring bone density in osteoporosis]. Z Orthop Ihre Grenzgeb. 2001; 139(5):M91-2. View

Du Z, Chen J, Yan F, Doan N, Ivanovski S, Xiao Y . Serum bone formation marker correlation with improved osseointegration in osteoporotic rats treated with simvastatin. Clin Oral Implants Res. 2011; 24(4):422-7. DOI: 10.1111/j.1600-0501.2011.02341.x. View

10.

Noor Z, Sumitro S, Hidayat M, Rahim A, Sabarudin A, Umemura T . Atomic mineral characteristics of Indonesian osteoporosis by high-resolution inductively coupled plasma mass spectrometry. ScientificWorldJournal. 2012; 2012:372972. PMC: 3361221. DOI: 10.1100/2012/372972. View

11.

Sabine Becker J, Zoriy M, Matusch A, Wu B, Salber D, Palm C . Bioimaging of metals by laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS). Mass Spectrom Rev. 2009; 29(1):156-75. DOI: 10.1002/mas.20239. View

12.

Kindness A, Sekaran C, Feldmann J . Two-dimensional mapping of copper and zinc in liver sections by laser ablation-inductively coupled plasma mass spectrometry. Clin Chem. 2003; 49(11):1916-23. DOI: 10.1373/clinchem.2003.022046. View

13.

Sabine Becker J, Matusch A, Wu B . Bioimaging mass spectrometry of trace elements - recent advance and applications of LA-ICP-MS: A review. Anal Chim Acta. 2014; 835:1-18. DOI: 10.1016/j.aca.2014.04.048. View

14.

Khosla S . Minireview: the OPG/RANKL/RANK system. Endocrinology. 2001; 142(12):5050-5. DOI: 10.1210/endo.142.12.8536. View

15.

Zijlstra W, Bulstra S, van Raay J, van Leeuwen B, Kuijer R . Cobalt and chromium ions reduce human osteoblast-like cell activity in vitro, reduce the OPG to RANKL ratio, and induce oxidative stress. J Orthop Res. 2011; 30(5):740-7. DOI: 10.1002/jor.21581. View

16.

Hohlweg-Majert B, Schmelzeisen R, Pfeiffer B, Schneider E . Significance of osteoporosis in craniomaxillofacial surgery: a review of the literature. Osteoporos Int. 2005; 17(2):167-79. DOI: 10.1007/s00198-005-1967-4. View

17.

Alfven T, Elinder C, Carlsson M, Grubb A, Hellstrom L, Persson B . Low-level cadmium exposure and osteoporosis. J Bone Miner Res. 2000; 15(8):1579-86. DOI: 10.1359/jbmr.2000.15.8.1579. View

18.

Zhang Y, Chen L, Zeng J, Zhou K, Zhang D . Aligned porous barium titanate/hydroxyapatite composites with high piezoelectric coefficients for bone tissue engineering. Mater Sci Eng C Mater Biol Appl. 2014; 39:143-9. DOI: 10.1016/j.msec.2014.02.022. View

19.

Brendlinger D, TARSITANO J . Generalized dermatitis due to sensitivity to a chrome cobalt removable partial denture. J Am Dent Assoc. 1970; 81(2):392-4. DOI: 10.14219/jada.archive.1970.0199. View

20.

Ovesen J, Moller-Madsen B, Nielsen P, Hedevang Christensen P, Simonsen O, Hoeck H . Differences in zinc status between patients with osteoarthritis and osteoporosis. J Trace Elem Med Biol. 2009; 23(1):1-8. DOI: 10.1016/j.jtemb.2008.12.001. View