Mechanisms of DNA Repair by Photolyase and Excision Nuclease (Nobel Lecture)

Overview

Journal Angew Chem Int Ed Engl

Specialty Chemistry

Date 2016 Jun 24

PMID 27337655

Citations 116

Authors

Aziz Sancar

Affiliations

Soon will be listed here.

Abstract

Ultraviolet light damages DNA by converting two adjacent thymines into a thymine dimer which is potentially mutagenic, carcinogenic, or lethal to the organism. This damage is repaired by photolyase and the nucleotide excision repair system in E. coli by nucleotide excision repair in humans. The work leading to these results is presented by Aziz Sancar in his Nobel Lecture.

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