Bacterial Metabolism Shapes the Host-Pathogen Interface

Overview

Journal Microbiol Spectr

Specialty Microbiology

Date 2016 Jun 24

PMID 27337445

Citations 46

Authors

Karla D Passalacqua

Marie-Eve Charbonneau

Mary X D ORiordan

Affiliations

Soon will be listed here.

Abstract

Bacterial pathogens have evolved to exploit humans as a rich source of nutrients to support survival and replication. The pathways of bacterial metabolism that permit successful colonization are surprisingly varied and highlight remarkable metabolic flexibility. The constraints and immune pressures of distinct niches within the human body set the stage for understanding the mechanisms by which bacteria acquire critical nutrients. In this article we discuss how different bacterial pathogens carry out carbon and energy metabolism in the host and how they obtain or use key nutrients for replication and immune evasion.

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References

Franza T, Expert D . Role of iron homeostasis in the virulence of phytopathogenic bacteria: an 'à la carte' menu. Mol Plant Pathol. 2012; 14(4):429-38. PMC: 6638640. DOI: 10.1111/mpp.12007. View

Drago-Serrano M, Parra S, Manjarrez-Hernandez H . EspC, an autotransporter protein secreted by enteropathogenic Escherichia coli (EPEC), displays protease activity on human hemoglobin. FEMS Microbiol Lett. 2006; 265(1):35-40. DOI: 10.1111/j.1574-6968.2006.00463.x. View

Cartron M, Maddocks S, Gillingham P, Craven C, Andrews S . Feo--transport of ferrous iron into bacteria. Biometals. 2006; 19(2):143-57. DOI: 10.1007/s10534-006-0003-2. View

Almagro-Moreno S, Boyd E . Bacterial catabolism of nonulosonic (sialic) acid and fitness in the gut. Gut Microbes. 2011; 1(1):45-50. PMC: 3035139. DOI: 10.4161/gmic.1.1.10386. View

Martinez F, Gordon S . The M1 and M2 paradigm of macrophage activation: time for reassessment. F1000Prime Rep. 2014; 6:13. PMC: 3944738. DOI: 10.12703/P6-13. View

Sonnenburg J, Xu J, Leip D, Chen C, Westover B, Weatherford J . Glycan foraging in vivo by an intestine-adapted bacterial symbiont. Science. 2005; 307(5717):1955-9. DOI: 10.1126/science.1109051. View

Klein J, Lewinson O . Bacterial ATP-driven transporters of transition metals: physiological roles, mechanisms of action, and roles in bacterial virulence. Metallomics. 2011; 3(11):1098-108. DOI: 10.1039/c1mt00073j. View

Gevers D, Knight R, Petrosino J, Huang K, McGuire A, Birren B . The Human Microbiome Project: a community resource for the healthy human microbiome. PLoS Biol. 2012; 10(8):e1001377. PMC: 3419203. DOI: 10.1371/journal.pbio.1001377. View

Coates R, Moran J, Horsburgh M . Staphylococci: colonizers and pathogens of human skin. Future Microbiol. 2013; 9(1):75-91. DOI: 10.2217/fmb.13.145. View

10.

Moye Z, Zeng L, Burne R . Fueling the caries process: carbohydrate metabolism and gene regulation by Streptococcus mutans. J Oral Microbiol. 2014; 6. PMC: 4157138. DOI: 10.3402/jom.v6.24878. View

11.

Hood M, Skaar E . Nutritional immunity: transition metals at the pathogen-host interface. Nat Rev Microbiol. 2012; 10(8):525-37. PMC: 3875331. DOI: 10.1038/nrmicro2836. View

12.

Sassetti C, Rubin E . Genetic requirements for mycobacterial survival during infection. Proc Natl Acad Sci U S A. 2003; 100(22):12989-94. PMC: 240732. DOI: 10.1073/pnas.2134250100. View

13.

MacKenzie C, Gonzalez R, Kniep E, Roch S, Daubener W . Cytokine mediated regulation of interferon-gamma-induced IDO activation. Adv Exp Med Biol. 2000; 467:533-9. DOI: 10.1007/978-1-4615-4709-9_66. View

14.

Chaturvedi K, Hung C, Crowley J, Stapleton A, Henderson J . The siderophore yersiniabactin binds copper to protect pathogens during infection. Nat Chem Biol. 2012; 8(8):731-6. PMC: 3600419. DOI: 10.1038/nchembio.1020. View

15.

Bowden S, Rowley G, Hinton J, Thompson A . Glucose and glycolysis are required for the successful infection of macrophages and mice by Salmonella enterica serovar typhimurium. Infect Immun. 2009; 77(7):3117-26. PMC: 2708584. DOI: 10.1128/IAI.00093-09. View

16.

Thammavongsa V, Kern J, Missiakas D, Schneewind O . Staphylococcus aureus synthesizes adenosine to escape host immune responses. J Exp Med. 2009; 206(11):2417-27. PMC: 2768845. DOI: 10.1084/jem.20090097. View

17.

Kehl-Fie T, Zhang Y, Moore J, Farrand A, Hood M, Rathi S . MntABC and MntH contribute to systemic Staphylococcus aureus infection by competing with calprotectin for nutrient manganese. Infect Immun. 2013; 81(9):3395-405. PMC: 3754211. DOI: 10.1128/IAI.00420-13. View

18.

Cole S, Brosch R, Parkhill J, Garnier T, Churcher C, Harris D . Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Nature. 1998; 393(6685):537-44. DOI: 10.1038/31159. View

19.

Andreini C, Banci L, Bertini I, Rosato A . Zinc through the three domains of life. J Proteome Res. 2006; 5(11):3173-8. DOI: 10.1021/pr0603699. View

20.

Curtis M, Hu Z, Klimko C, Narayanan S, DeBerardinis R, Sperandio V . The gut commensal Bacteroides thetaiotaomicron exacerbates enteric infection through modification of the metabolic landscape. Cell Host Microbe. 2014; 16(6):759-69. PMC: 4269104. DOI: 10.1016/j.chom.2014.11.005. View