Pathophysiological Significance of Hepatic Apoptosis

Overview

Journal ISRN Hepatol

Specialty Gastroenterology

Date 2016 Jun 24

PMID 27335822

Citations 13

Authors

KeWei Wang

Bingliang Lin

Affiliations

Soon will be listed here.

Abstract

Apoptosis is a classical pathological feature in liver diseases caused by various etiological factors such as drugs, viruses, alcohol, and cholestasis. Hepatic apoptosis and its deleterious effects exacerbate liver function as well as involvement in fibrosis/cirrhosis and carcinogenesis. An imbalance between apoptotic and antiapoptotic capabilities is a prominent characteristic of liver injury. The regulation of apoptosis and antiapoptosis can be a pivotal step in the treatment of liver diseases.

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References

Fuest M, Willim K, MacNelly S, Fellner N, Resch G, Blum H . The transcription factor c-Jun protects against sustained hepatic endoplasmic reticulum stress thereby promoting hepatocyte survival. Hepatology. 2011; 55(2):408-18. DOI: 10.1002/hep.24699. View

Wang K, Brems J, Gamelli R, Holterman A . C/EBPα and C/EBPβ binding proteins modulate hepatocyte apoptosis through iNOS signaling pathway. Biochim Biophys Acta. 2011; 1813(8):1395-403. DOI: 10.1016/j.bbamcr.2011.04.004. View

Behrens A, Sibilia M, Wagner E . Amino-terminal phosphorylation of c-Jun regulates stress-induced apoptosis and cellular proliferation. Nat Genet. 1999; 21(3):326-9. DOI: 10.1038/6854. View

Reed J . Bcl-2 family proteins. Oncogene. 1999; 17(25):3225-36. DOI: 10.1038/sj.onc.1202591. View

Takahashi R, Deveraux Q, Tamm I, Welsh K, Salvesen G, Reed J . A single BIR domain of XIAP sufficient for inhibiting caspases. J Biol Chem. 1998; 273(14):7787-90. DOI: 10.1074/jbc.273.14.7787. View

Kouzarides T, Ziff E . Behind the Fos and Jun leucine zipper. Cancer Cells. 1989; 1(3):71-6. View

Mazumdar B, Meyer K, Ray R . N-terminal region of gelsolin induces apoptosis of activated hepatic stellate cells by a caspase-dependent mechanism. PLoS One. 2012; 7(8):e44461. PMC: 3430645. DOI: 10.1371/journal.pone.0044461. View

Hikita H, Takehara T, Kodama T, Shimizu S, Hosui A, Miyagi T . BH3-only protein bid participates in the Bcl-2 network in healthy liver cells. Hepatology. 2009; 50(6):1972-80. PMC: 3560855. DOI: 10.1002/hep.23207. View

Ghibelli L, Diederich M . Multistep and multitask Bax activation. Mitochondrion. 2010; 10(6):604-13. DOI: 10.1016/j.mito.2010.08.003. View

10.

Pritchard D, Butler W . Apoptosis--the mechanism of cell death in dimethylnitrosamine-induced hepatotoxicity. J Pathol. 1989; 158(3):253-60. DOI: 10.1002/path.1711580314. View

11.

Kluck R, Bossy-Wetzel E, Green D, Newmeyer D . The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis. Science. 1997; 275(5303):1132-6. DOI: 10.1126/science.275.5303.1132. View

12.

Malhi H, Gores G, Lemasters J . Apoptosis and necrosis in the liver: a tale of two deaths?. Hepatology. 2006; 43(2 Suppl 1):S31-44. DOI: 10.1002/hep.21062. View

13.

Miyoshi H, Rust C, Roberts P, Burgart L, Gores G . Hepatocyte apoptosis after bile duct ligation in the mouse involves Fas. Gastroenterology. 1999; 117(3):669-77. DOI: 10.1016/s0016-5085(99)70461-0. View

14.

Runyan C, Schaible K, Molyneaux K, Wang Z, Levin L, Wylie C . Steel factor controls midline cell death of primordial germ cells and is essential for their normal proliferation and migration. Development. 2006; 133(24):4861-9. DOI: 10.1242/dev.02688. View

15.

Mullauer L, Gruber P, Sebinger D, Buch J, Wohlfart S, Chott A . Mutations in apoptosis genes: a pathogenetic factor for human disease. Mutat Res. 2001; 488(3):211-31. DOI: 10.1016/s1383-5742(01)00057-6. View

16.

Yuen M, Wu P, Lai V, Lau J, Lai C . Expression of c-Myc, c-Fos, and c-jun in hepatocellular carcinoma. Cancer. 2001; 91(1):106-12. DOI: 10.1002/1097-0142(20010101)91:1<106::aid-cncr14>3.0.co;2-2. View

17.

Lee W . Drug-induced hepatotoxicity. N Engl J Med. 2003; 349(5):474-85. DOI: 10.1056/NEJMra021844. View

18.

Bratton S, MacFarlane M, Cain K, Cohen G . Protein complexes activate distinct caspase cascades in death receptor and stress-induced apoptosis. Exp Cell Res. 2000; 256(1):27-33. DOI: 10.1006/excr.2000.4835. View

19.

Raff M, Barres B, Burne J, Coles H, Ishizaki Y, Jacobson M . Programmed cell death and the control of cell survival: lessons from the nervous system. Science. 1993; 262(5134):695-700. DOI: 10.1126/science.8235590. View

20.

Geller D, Freeswick P, Nguyen D, Nussler A, Di Silvio M, Shapiro R . Differential induction of nitric oxide synthase in hepatocytes during endotoxemia and the acute-phase response. Arch Surg. 1994; 129(2):165-71. DOI: 10.1001/archsurg.1994.01420260061008. View