Thiol Redox and PKa Properties of Mycothiol, the Predominant Low-Molecular-Weight Thiol Cofactor in the Actinomycetes

Overview

Journal Chembiochem

Specialty Biochemistry

Date 2016 Jun 23

PMID 27332744

Citations 11

Authors

Sunil V Sharma

Koen Van Laer

Joris Messens

Chris J Hamilton

Affiliations

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Abstract

The thiol pKa and standard redox potential of mycothiol, the major low-molecular-weight thiol cofactor in the actinomycetes, are reported. The measured standard redox potential reveals substantial discrepancies in one or more of the other previously measured intracellular parameters that are relevant to mycothiol redox biochemistry.

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