Clinical Association of Baseline Levels of Conjugated Dienes in Low-density Lipoprotein and Nitric Oxide with Aggressive B-cell Non-Hodgkin Lymphoma and Their Relationship with Immunoglobulins and Th1-to-Th2 Ratio

Overview

Journal J Blood Med

Publisher Dove Medical Press

Specialty Hematology

Date 2016 Jun 23

PMID 27330333

Citations 3

Authors

Mustapha Haddouche

Warda Meziane

Zeyneb Hadjidj

Naima Mesli

Mourad Aribi

Affiliations

Soon will be listed here.

Abstract

Objective: The aim of this study was to highlight the clinical association of baseline levels of conjugated dienes in low-density lipoprotein (LDL-BCD) and nitric oxide (NO) with immunoglobulins (Igs) and T helper (Th)1/Th2 ratio in patients with newly diagnosed B-cell non-Hodgkin lymphoma (NHL).

Patients And Methods: Thirty-two newly diagnosed patients with aggressive B-cell NHL and 25 age-, sex-, and body-mass-index-matched healthy controls were randomly selected for a cross-sectional case-control study conducted at the Hematology Department of Tlemcen Medical Centre University (northwest of Algeria).

Results: Circulating levels of LDL-BCD and NO and those of IgA and IgM were significantly higher in patients than in controls. The levels of Th1/Th2 ratio and plasma total antioxidant capacity were significantly lower in patients compared with controls, while malondialdehyde and protein carbonyl levels were significantly higher in patients. B-cell NHL was significantly associated with high levels of LDL-BCD from 25th to 75th percentile (25th percentile: relative risk [RR] =2.26, 95% confidence interval [CI] 1.42-3.59, P=0.014; 50th percentile: RR =2.84, 95% CI 1.72-4.68, P<0.001; 75th percentile: RR =5.43, 95% CI 2.58-11.42, P<0.001). Similarly, the disease was significantly associated with high levels of NO production from 25th to 75th percentile (25th percentile: RR =2.07, 95% CI 1.25-3.44, P=0.024; 50th percentile: RR =2.78, 95% CI 1.63-4.72, P<0.001; 75th percentile: RR =4.68, 95% CI 2.21-9.91, P<0.001). Moreover, LDL-BCD levels were positively and significantly correlated with interferon (IFN)-γ, whereas NO levels were inversely and significantly correlated with IFN-γ and Th1/Th2 ratio.

Conclusion: LDL-BCD and NO production seem to be associated with aggressive B-cell NHL and alteration of Th1/Th2 ratio. Our results have to be examined using ex vivo mechanistic studies leading to further investigations of these parameters, with an interest in the link between Epstein-Barr virus infection and NO and immunoglobulins.

Citing Articles

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Protein Carbonylation and Lipid Peroxidation in Hematological Malignancies.

Rodriguez-Garcia A, Garcia-Vicente R, Morales M, Ortiz-Ruiz A, Martinez-Lopez J, Linares M Antioxidants (Basel). 2020; 9(12).

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Identification of Hub Genes and Key Pathways Associated with Two Subtypes of Diffuse Large B-Cell Lymphoma Based on Gene Expression Profiling via Integrated Bioinformatics.

Liu Z, Meng J, Li X, Zhu F, Liu T, Wu G Biomed Res Int. 2018; 2018:3574534.

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