Tumor Growth Affects the Metabonomic Phenotypes of Multiple Mouse Non-involved Organs in an A549 Lung Cancer Xenograft Model

Overview

Journal Sci Rep

Specialty Science

Date 2016 Jun 23

PMID 27329570

Citations 6

Authors

Shan Xu

Yuan Tian

Yili Hu

Nijia Zhang

Sheng Hu

Dandan Song

Zhengshun Wu

Yulan Wang

Yanfang Cui

Huiru Tang

Affiliations

Soon will be listed here.

Abstract

The effects of tumorigenesis and tumor growth on the non-involved organs remain poorly understood although many research efforts have already been made for understanding the metabolic phenotypes of various tumors. To better the situation, we systematically analyzed the metabolic phenotypes of multiple non-involved mouse organ tissues (heart, liver, spleen, lung and kidney) in an A549 lung cancer xenograft model at two different tumor-growth stages using the NMR-based metabonomics approaches. We found that tumor growth caused significant metabonomic changes in multiple non-involved organ tissues involving numerous metabolic pathways, including glycolysis, TCA cycle and metabolisms of amino acids, fatty acids, choline and nucleic acids. Amongst these, the common effects are enhanced glycolysis and nucleoside/nucleotide metabolisms. These findings provided essential biochemistry information about the effects of tumor growth on the non-involved organs.

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