Relationship Between Platelet Parameters and Hepatic Pathology in Patients with Chronic Hepatitis B Infection - a Retrospective Cohort Study of 677 Patients

Overview

Journal J Int Med Res

Publisher Sage Publications

Specialty General Medicine

Date 2016 Jun 23

PMID 27329384

Citations 8

Authors

Ye Pan

Aikeremujiang Muheremu

Xiaolu Wu

Jiajun Liu

Affiliations

Soon will be listed here.

Abstract

Objective: A retrospective study to determine the relationships between platelet parameters and inflammation and fibrosis of the liver in patients with chronic hepatitis B virus infection (CHB).

Methods: Patients with liver biopsy-confirmed CHB were included in the study. Liver fibrosis and inflammation were assessed by histopathology of biopsied liver tissue. Platelet count (PLT), platelet distribution width (PDW) and mean platelet volume (MPV) were determined as part of routine blood tests. The relationship between inflammation and fibrosis and platelet parameters were analysed by multiple linear regression.

Results: The study included 677 patients. PLT and PDW accounted for 20.5% of liver inflammation. PLT and PDW accounted for 18.4% of liver fibrosis.

Conclusion: Platelet parameters can provide valuable information for the assessment of hepatic inflammation and fibrosis.

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