Theoretical Study of Genetic Variability, Assuming Stepwise Production of Neutral and Very Slightly Deleterious Mutations

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 1978 Feb 1

PMID 273253

Citations 4

Authors

T Maruyama

M Kimura

Affiliations

Soon will be listed here.

Abstract

Mathematical treatments are presented that enable us to compute the amount of genetic variability maintained in a finite population, assuming that mutations occur in stepwise fashion and that both selectively neutral and slightly deleterious alleles are involved. Two numerical examples show that, if very slightly deleterious mutations are prevalent, the amount of genetic variability increases much more slowly as the population number increases than is the case when all the mutations are strictly neutral.

Citing Articles

Model of effectively neutral mutations in which selective constraint is incorporated.

Kimura M Proc Natl Acad Sci U S A. 1979; 76(7):3440-4.

PMID: 16592684 PMC: 383841. DOI: 10.1073/pnas.76.7.3440.

Stationary gene frequency distribution in the environment fluctuating between two distinct states.

Matsuda H, Ishii K J Math Biol. 1981; 11(2):119-41.

PMID: 7276760 DOI: 10.1007/BF00275437.

Composite stepwise mutation model under the neutral mutation hypothesis.

Takahata N J Mol Evol. 1980; 15(1):13-20.

PMID: 6928979 DOI: 10.1007/BF01732579.

Stepwise mutation model and distribution of allelic frequencies in a finite population.

Kimura M, Ohta T Proc Natl Acad Sci U S A. 1978; 75(6):2868-72.

PMID: 275857 PMC: 392666. DOI: 10.1073/pnas.75.6.2868.

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