The Paradox of Dicer in Cancer

Overview

Journal Mol Cell Oncol

Specialty Oncology

Date 2016 Jun 18

PMID 27314098

Citations 15

Authors

Vijay Swahari

Ayumi Nakamura

Mohanish Deshmukh

Affiliations

Soon will be listed here.

Abstract

Dicer has been well studied in cancer; however, deciphering its exact function in tumorigenesis continues to be a challenge. While partial suppression or truncation of Dicer promotes tumorigenesis, its complete deletion inhibits tumor growth. Here, we discuss this Dicer cancer conundrum in the context of its recently discovered role in the DNA damage response.

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