Cell-in-cell Structures Are Involved in the Competition Between Cells in Human Tumors

Overview

Journal Mol Cell Oncol

Specialty Oncology

Date 2016 Jun 17

PMID 27308493

Citations 20

Authors

Qiang Sun

Hongyan Huang

Michael Overholtzer

Affiliations

Soon will be listed here.

Abstract

The engulfment of live cells may represent a mechanism of cell death. We reported that E-cadherin (epithelial cadherin) expression in human cancer cells favors the formation of cell-in-cell structures through the mechanism known as entosis, and that entosis contributes to a form of cellular competition in heterogeneous cancer cell populations.

Citing Articles

Homotypic cell-in-cell structure as a novel prognostic predictor in non-small cell lung cancer and frequently localized at the invasive front.

Liu X, Guo R, Li D, Wang Y, Ning J, Yang S Sci Rep. 2024; 14(1):18952.

PMID: 39147858 PMC: 11327305. DOI: 10.1038/s41598-024-69833-2.

Mechanisms and significance of entosis for tumour growth and progression.

Gaptulbarova K, Tsydenova I, Dolgasheva D, Kravtsova E, Ibragimova M, Vtorushin S Cell Death Discov. 2024; 10(1):109.

PMID: 38429285 PMC: 10907354. DOI: 10.1038/s41420-024-01877-9.

Mapping Cell-in-Cell Structures in Oral Squamous Cell Carcinoma.

Siquara da Rocha L, Souza B, Coletta R, Lambert D, Gurgel Rocha C Cells. 2023; 12(19).

PMID: 37830632 PMC: 10572403. DOI: 10.3390/cells12192418.

Subtype-based analysis of cell-in-cell structures in non-small cell lung cancer.

Wei Y, Niu Z, Hou X, Liu M, Wang Y, Zhou Y Am J Cancer Res. 2023; 13(3):1091-1102.

PMID: 37034205 PMC: 10077035.

Tumor malignancy by genetic transfer between cells forming cell-in-cell structures.

Wang R, Zhong H, Wang C, Huang X, Huang A, Du N Cell Death Dis. 2023; 14(3):195.

PMID: 36914619 PMC: 10011543. DOI: 10.1038/s41419-023-05707-1.

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