Computational Studies on Pterins and Speculations on the Mechanism of Action of Dihydrofolate Reductase

Overview

Journal Biochem Biophys Res Commun

Publisher Elsevier

Specialty Biochemistry

Date 1989 May 30

PMID 2730668

Citations 3

Authors

T Uchimaru

S Tsuzuki

K Tanabe

S J Benkovic

K Furukawa

K Taira

Affiliations

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Abstract

The significance of the enol form of the pterin ring in enzymatic reduction of dihydrofolate by DHFR is discussed on the basis of the results of ab initio calculations carried out on the keto/enol tautomers of 6-methyl-7, 8-dihydropterin as the model compound for the natural substrate, dihydrofolate.

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