A Ribosomal Perspective on Proteostasis and Aging

Overview

Journal Cell Metab

Publisher Cell Press

Specialties Cell Biology
Endocrinology

Date 2016 Jun 16

PMID 27304502

Citations 79

Authors

Kristan K Steffen

Andrew Dillin

Affiliations

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Abstract

As the first and most direct process influencing the proteostasis capacity of a cell, regulation of translation influences lifespan across taxa. Here we highlight some of the newly discovered means by which translational regulation affects cellular proteostasis, with a focus on mechanisms that may ultimately impinge upon the aging process.

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