Antiplatelet and Antithrombotic Effects of the Extract of Leaves

Overview

Journal Biomol Ther (Seoul)

Specialty Pharmacology

Date 2016 Jun 16

PMID 27302963

Citations 13

Authors

Jun Ho Kim

Jaemin Lee

Soouk Kang

Hongsik Moon

Kyung Ho Chung

Kyoung Rak Kim

Affiliations

Soon will be listed here.

Abstract

has been used in traditional herbal medicine for the treatment of blood stasis and inflammation. The leaves of have been reported to exhibit various physiological activities. However, there is little information available on their antiplatelet and antithrombotic activities. Thus, the present study aimed to evaluate the effect of leaf extract (LLE) on platelet activities, coagulation and thromboembolism. In a platelet aggregation study, LLE significantly inhibited various agonist-induced platelet aggregations and . Furthermore, LLE significantly inhibited collagen-induced thromboxane A2 (TXA2) production in rat platelets. In addition, oral administration of LLE was protective in a mouse model of pulmonary thromboembolism induced by intravenous injection of a mixture of collagen and epinephrine. Interestingly, LLE did not significantly alter prothrombin time (PT) and activated partial thromboplastin time (aPTT). This study indicates that the antithrombotic effects of LLE might be due to its antiplatelet activities rather than anticoagulation. Taken together, these results suggest that LLE may be a candidate preventive and therapeutic agent in cardiovascular diseases associated with platelet hyperactivity.

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