Cytotoxic Labdane Diterpenes from Hedychium Ellipticum Buch.-Ham. Ex Sm

Overview

Journal Molecules

Publisher MDPI

Specialty Biology

Date 2016 Jun 14

PMID 27294893

Citations 7

Authors

Sineenard Songsri

Nuchnipa Nuntawong

Affiliations

Soon will be listed here.

Abstract

In order to reveal the constituents and their biological activities, we carried out a phytochemical study on Hedychium ellipticum Buch.-Ham. ex Sm. (Zingiberaceae). Ten labdane diterpenoids (1-10) were isolated from the rhizomes of H. ellipticum for the first time. Their structures were identified on the basis of spectroscopic analyses including two-dimensional NMR and comparison with literature data. All of these compounds were evaluated for their antimycobacterial activity against Mycobacterium tuberculosis and cytotoxicity against KB, MCF7, NCI-H187 and Vero cells. The result showed that compounds 1 and 7 exhibited moderate activity against Mycobacterium tuberculosis and compounds 4, 6 and 7 displayed remarkable cytotoxic activity. This is the first report on the presence of all compounds in H. ellipticum and the first time that their structure activity relationship has been discussed.

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