Hidradenitis Suppurativa/Acne Inversa: an Endocrine Skin Disorder?

Overview

Journal Rev Endocr Metab Disord

Publisher Springer

Specialty Endocrinology

Date 2016 Jun 14

PMID 27294593

Citations 22

Authors

Ioannis Karagiannidis

Georgios Nikolakis

Robert Sabat

Christos C Zouboulis

Affiliations

Soon will be listed here.

Abstract

Hidradenitis suppurativa / acne inversa (HS) is a chronic inflammatory, debilitating skin disorder with a largely unknown etiology. However, many observations such as the typical onset of the disease after puberty, the female predominance, the pre-menstrual flare ups and the improvement during pregnancy suggest a contribution of endocrinological factors to the emergence of the disease. In addition, the reported efficacy of anti-androgen treatment on HS indicates a possible involvement of androgens in the pathogenesis. Furthermore, the common comorbidity with metabolic syndrome points to possible interactions between endocrinological and metabolic alterations in the development of HS. Taking into account the endocrine functions of the human skin, several studies investigated the effects of hormones and the behavior of the pilosebaceous unit in the skin of patients with HS. In this review we describe the current view on the hormonal dysregulation and metabolic syndrome and their role in HS.

Citing Articles

A Pilot Real-World Study of Ultrasonography Findings of Hidradenitis Suppurativa in Indian Patients and Its Diagnostic and Therapeutic Implications.

Gogate S, Aggarwal R, Sardana K, Yadav S, Boyidi B, Siddharth S Indian J Radiol Imaging. 2024; 34(4):603-611.

PMID: 39318584 PMC: 11419750. DOI: 10.1055/s-0044-1782624.

Hidradenitis suppurativa as a potential risk factor of periodontitis: a multi-center, propensity-score-matched cohort study.

Gau S, Guo Y, Lu H, Lin C, Lee C, Tsai R Int J Med Sci. 2024; 21(5):874-881.

PMID: 38617008 PMC: 11008474. DOI: 10.7150/ijms.93178.

Hidradenitis Suppurativa: An Interdisciplinary Problem in Dermatology, Gynecology, and Surgery-Pathogenesis, Comorbidities, and Current Treatments.

Nowak-Liduk A, Kitala D, Ochala-Gierek G, Labus W, Bergler-Czop B, Pietrauszka K Life (Basel). 2023; 13(9).

PMID: 37763299 PMC: 10532726. DOI: 10.3390/life13091895.

Bone Metabolism in Patients with Hidradenitis Suppurativa: A Case-control Study.

Navarro I, Gonzalez-Lopez M, Sierra I, Olmos J, Blanco R, Hernandez J Acta Derm Venereol. 2022; 102:adv00825.

PMID: 36444563 PMC: 9811290. DOI: 10.2340/actadv.v102.3504.

Sex-disaggregated population analysis in patients with hidradenitis suppurativa.

Sabat R, Tsaousi A, Ghoreschi K, Wolk K, Schneider-Burrus S Front Med (Lausanne). 2022; 9:1028943.

PMID: 36388895 PMC: 9663462. DOI: 10.3389/fmed.2022.1028943.

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