Environmental Exposure to BDE47 is Associated with Increased Diabetes Prevalence: Evidence from Community-based Case-control Studies and an Animal Experiment

Overview

Journal Sci Rep

Specialty Science

Date 2016 Jun 14

PMID 27291303

Citations 27

Authors

Zhan Zhang

Shushu Li

Lu Liu

Li Wang

Xue Xiao

Zhenzhen Sun

Xichen Wang

Chao Wang

Meilin Wang

Lei Li

Qiujin Xu

Weimin Gao

Shou-Lin Wang

Affiliations

Soon will be listed here.

Abstract

Brominated flame retardants exposure has been associated with increasing trends of diabetes and metabolic disease. Thus, the purpose of this study was to provide evidence of polybrominated diphenyl ethers (PBDEs) exposure in relation to diabetes prevalence and to reveal the potential underlying mechanism in epidemiological and animal studies. All the participants received a questionnaire, health examination, and the detection of 7 PBDE congeners in serum in two independent community-based studies from 2011 to 2012 in China. Male rats were exposed to 2,2'4,4'-tetrabromodiphenyl ether (BDE47) for 8 weeks to explore its effects on glucose homeostasis and potential mechanisms using high-throughput genomic analysis. Among the 7 congeners, BDE47 showed significant high detection rate and concentration in cases in Study I and Study II. Every tertile of BDE47 exposure significantly increased the risk of diabetes prevalence in Study I (Ptrend = 0.001) and Study II (Ptrend < 0.001). Additionally, BDE47 treatments induced hyperglycemia in rats. Furthermore, gene microarray analysis showed that diabetes pathway and three gene ontology terms involved in glucose transport were enriched. The results indicated that environmental exposure to BDE47 was associated with increased diabetes prevalence. However, further prospective and mechanistic studies are needed to the causation of diabetes in relation to BDE47.

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