A Combined Modality Therapeutic Approach to Metastatic Anal Squamous Cell Carcinoma with Systemic Chemotherapy and Local Therapy to Sites of Disease: Case Report and Review of Literature

Overview

Journal J Gastrointest Oncol

Date 2016 Jun 11

PMID 27284490

Citations 3

Authors

Rosana Gnanajothy

Graham W Warren

Sherry Okun

Lindsay L Peterson

Affiliations

Soon will be listed here.

Abstract

Cases of metastatic anal carcinoma managed with a combination of systemic chemotherapy and local therapies to both solitary sites of metastases and the primary site have been reported in the literature. We present a case of a 55-year-old male with metastatic anal squamous cell carcinoma to the liver treated with induction chemotherapy with cisplatin (CDDP) and 5-fluorouracil (5FU) followed by liver resection and radiation to the anal primary with concurrent 5FU and mitomycin. This approach resulted in control of disease without evidence of recurrence, and no increased toxicities now 19 months from initial diagnosis to time of reporting. This novel approach resulted in a good treatment response as documented by imaging and symptom improvement and a long disease free interval.

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