MicroRNAs in Glioblastoma Multiforme Pathogenesis and Therapeutics

Overview

Journal Cancer Med

Specialty Oncology

Date 2016 Jun 11

PMID 27282910

Citations 104

Authors

Amanda Shea

Varsha Harish

Zainab Afzal

Juliet Chijioke

Habib Kedir

Shahnoza Dusmatova

Arpita Roy

Malathi Ramalinga

Brent Harris

Jan Blancato

Mukesh Verma

Deepak Kumar

Affiliations

Soon will be listed here.

Abstract

Glioblastoma multiforme (GBM) is the most common and lethal cancer of the adult brain, remaining incurable with a median survival time of only 15 months. In an effort to identify new targets for GBM diagnostics and therapeutics, recent studies have focused on molecular phenotyping of GBM subtypes. This has resulted in mounting interest in microRNAs (miRNAs) due to their regulatory capacities in both normal development and in pathological conditions such as cancer. miRNAs have a wide range of targets, allowing them to modulate many pathways critical to cancer progression, including proliferation, cell death, metastasis, angiogenesis, and drug resistance. This review explores our current understanding of miRNAs that are differentially modulated and pathologically involved in GBM as well as the current state of miRNA-based therapeutics. As the role of miRNAs in GBM becomes more well understood and novel delivery methods are developed and optimized, miRNA-based therapies could provide a critical step forward in cancer treatment.

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