Association of TNFα, IFNγ, and IL10 Gene Polymorphisms and the Risk of Non-small Cell Lung Cancer in the Population of the South Indian State of Telangana

Overview

Journal Int J Clin Oncol

Specialty Oncology

Date 2016 Jun 11

PMID 27282611

Citations 8

Authors

Vidyullatha Peddireddy

Siva Prasad Badabagni

Shehnaz Sulthana

Venkata Karunakar Kolla

Sandhya Devi Gundimeda

Hemaprasad Mundluru

Affiliations

Soon will be listed here.

Abstract

Background: Cytokine-mediated inflammation is important in the pathogenesis of non-small cell lung cancer (NSCLC). Genetic polymorphisms in cytokine genes and their association with lung cancer in the Indian population have not been reported.

Methods: For the first time, we analyzed genetic polymorphisms of TNFα , IFNγ , and IL10 genes in 246 NSCLC patients and 250 healthy controls in the South Indian population from Telangana using ARMS PCR.

Results: IFNγ A/T and IL10 G/G gene polymorphisms were found to be significantly associated with NSCLC with 1.56- and 1.68-fold disease risk, respectively. There was no association between the risk of NSCLC and TNFα polymorphism. Gene polymorphisms stratified according to smoking revealed that IFNγ A/T polymorphisms in smokers increased the disease risk by 2.91 fold. IL10 G/G polymorphisms showed 2-fold increased risk among patients who were smokers when compared to the controls. However, there was no association between TNFα, IFNγ, and IL10 gene polymorphism and the stage of the NSCLC patients. The overall risk associated with the combination of these polymorphisms indicated that the TNFα G/A + IFNγ A/T + IL10 G/G genotype increased the risk by 1.5 fold.

Conclusions: The results of our study indicate an association between cytokine gene polymorphisms and the risk of NSCLC in an Indian population.

Citing Articles

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Immunomodulatory gene polymorphisms in non-small cell lung carcinoma susceptibility and survival.

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References

Rovina N, Koutsoukou A, Koulouris N . Inflammation and immune response in COPD: where do we stand?. Mediators Inflamm. 2013; 2013:413735. PMC: 3728539. DOI: 10.1155/2013/413735. View

Ganesh B, Saoba S, Sarade M, Pinjari S . Risk factors for prostate cancer: An hospital-based case-control study from Mumbai, India. Indian J Urol. 2011; 27(3):345-50. PMC: 3193734. DOI: 10.4103/0970-1591.85438. View

Takizawa H, Tanaka M, Takami K, Ohtoshi T, Ito K, Satoh M . Increased expression of inflammatory mediators in small-airway epithelium from tobacco smokers. Am J Physiol Lung Cell Mol Physiol. 2000; 278(5):L906-13. DOI: 10.1152/ajplung.2000.278.5.L906. View

Raviv S, Hawkins K, DeCamp Jr M, Kalhan R . Lung cancer in chronic obstructive pulmonary disease: enhancing surgical options and outcomes. Am J Respir Crit Care Med. 2010; 183(9):1138-46. DOI: 10.1164/rccm.201008-1274CI. View

Sallakci N, Akcurin G, Koksoy S, Kardelen F, Uguz A, Coskun M . TNF-alpha G-308A polymorphism is associated with rheumatic fever and correlates with increased TNF-alpha production. J Autoimmun. 2005; 25(2):150-4. DOI: 10.1016/j.jaut.2005.05.005. View

Tarkowski E, Rosengren L, Blomstrand C, Wikkelso C, Jensen C, Ekholm S . Intrathecal release of pro- and anti-inflammatory cytokines during stroke. Clin Exp Immunol. 1997; 110(3):492-9. PMC: 1904815. DOI: 10.1046/j.1365-2249.1997.4621483.x. View

Perini F, Morra M, Alecci M, Galloni E, Marchi M, Toso V . Temporal profile of serum anti-inflammatory and pro-inflammatory interleukins in acute ischemic stroke patients. Neurol Sci. 2002; 22(4):289-96. DOI: 10.1007/s10072-001-8170-y. View

Wang Y, Sung W, Wang L, Cheng Y, Chen C, Wu T . Different impact of IL10 haplotype on prognosis in lung squamous cell carcinoma and adenocarcinoma. Anticancer Res. 2013; 33(6):2729-35. View

Natukula K, Jamil K, Pingali U, Attili V, Madireddy U . The codon 399 Arg/Gln XRCC1 polymorphism is associated with lung cancer in Indians. Asian Pac J Cancer Prev. 2013; 14(9):5275-9. DOI: 10.7314/apjcp.2013.14.9.5275. View

10.

Giovannetti E, Erdem L, Olcay E, Leon L, Peters G . Influence of polymorphisms on EGFR targeted therapy in non-small-cell lung cancer. Front Biosci (Landmark Ed). 2011; 16(1):116-30. DOI: 10.2741/3679. View

11.

Wang Y, Sung W, Wu T, Wang L, Chien W, Cheng Y . Interleukin-10 haplotype may predict survival and relapse in resected non-small cell lung cancer. PLoS One. 2012; 7(7):e39525. PMC: 3407146. DOI: 10.1371/journal.pone.0039525. View

12.

Shukla R, Kant S, Bhattacharya S, Mittal B . Association of cytokine gene polymorphisms in patients with chronic obstructive pulmonary disease. Oman Med J. 2012; 27(4):285-90. PMC: 3464746. DOI: 10.5001/omj.2012.71. View

13.

Chetty C, Rao J, Lakka S . Matrix metalloproteinase pharmacogenomics in non-small-cell lung carcinoma. Pharmacogenomics. 2011; 12(4):535-46. DOI: 10.2217/pgs.10.207. View

14.

Shih C, Lee Y, Chiou H, Chen W, Chang G, Chou M . Association of TNF-alpha polymorphism with susceptibility to and severity of non-small cell lung cancer. Lung Cancer. 2006; 52(1):15-20. DOI: 10.1016/j.lungcan.2005.11.011. View

15.

Seifart C, Plagens A, Dempfle A, Clostermann U, Vogelmeier C, von Wichert P . TNF-alpha, TNF-beta, IL-6, and IL-10 polymorphisms in patients with lung cancer. Dis Markers. 2005; 21(3):157-65. PMC: 3851050. DOI: 10.1155/2005/707131. View

16.

Coussens L, Werb Z . Inflammation and cancer. Nature. 2002; 420(6917):860-7. PMC: 2803035. DOI: 10.1038/nature01322. View

17.

Flego V, Ristic S, Devic Pavlic S, Lender D, Bulat-Kardum L, Kapovic M . Tumor necrosis factor-alpha gene promoter -308 and -238 polymorphisms in patients with lung cancer as a second primary tumor. Med Sci Monit. 2013; 19:846-51. PMC: 3808239. DOI: 10.12659/MSM.889554. View

18.

Liang J, Liu X, Bi Z, Yin B, Xiao J, Liu H . Relationship between gene polymorphisms of two cytokine genes (TNF-α and IL-6) and occurring of lung cancers in the ethnic group Han of China. Mol Biol Rep. 2012; 40(2):1541-6. DOI: 10.1007/s11033-012-2199-2. View

19.

Wang Y, Angkasekwinai P, Lu N, Voo K, Arima K, Hanabuchi S . IL-25 augments type 2 immune responses by enhancing the expansion and functions of TSLP-DC-activated Th2 memory cells. J Exp Med. 2007; 204(8):1837-47. PMC: 2118667. DOI: 10.1084/jem.20070406. View

20.

Tan T, Coussens L . Humoral immunity, inflammation and cancer. Curr Opin Immunol. 2007; 19(2):209-16. DOI: 10.1016/j.coi.2007.01.001. View