Pain and Itch: Beneficial or Harmful to Antimicrobial Defense?

Overview

Journal Cell Host Microbe

Publisher Cell Press

Specialties Infectious Diseases
Microbiology

Date 2016 Jun 10

PMID 27281567

Citations 17

Authors

Pankaj Baral

Kimbria Mills

Felipe A Pinho-Ribeiro

Isaac M Chiu

Affiliations

Soon will be listed here.

Abstract

Pain and itch are unpleasant sensations accompanying many microbial infections. Recent studies demonstrate that pain- and itch-mediating somatosensory neurons are able to directly detect pathogens, triggering neuronal activation and subsequent regulation of immune responses. We discuss whether pain and/or itch during infection is beneficial or harmful to host antimicrobial defense.

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