The Association Between Human Papillomavirus Infection and Female Lung Cancer: A Population-based Cohort Study

Overview

Journal Medicine (Baltimore)

Specialty General Medicine

Date 2016 Jun 10

PMID 27281096

Citations 20

Authors

Frank Cheau-Feng Lin

Jing-Yang Huang

Stella Ching-Shao Tsai

Oswald Ndi Nfor

Ming-Chih Chou

Ming-Fang Wu

Chun-Te Lee

Cheng-Feng Jan

Yung-Po Liaw

Affiliations

Soon will be listed here.

Abstract

Lung cancer is the leading cause of cancer deaths among Taiwanese women. Human papillomavirus (HPV) has been detected in lung cancer tissues. The aim of this study was to investigate the association between HPV infection and lung cancer among the Taiwanese women. The analytical data were collected from the longitudinal health insurance databases (LHID 2005 and 2010) of the National Health Insurance Research Database (NHIRD). The study participants were 30 years and older and included 24,162 individuals who were identified with HPV infection from 2001 to 2004 and 1,026,986 uninfected individuals. Lung cancer incidence among infected and uninfected individuals was compared using the univariate and multivariate regression models. Among the total participants, 24,162 individuals were diagnosed with HPV. After adjusting for age, gender, low income, residential area, and comorbidity, the risk of lung cancer was higher in women (hazard ratio [HR] 1.263, 95% CI 1.015-1.571), while all cancer risks were high in both men and women with corresponding hazard ratios (HR) of 1.161 (95% CI 1.083-1.245) and HR 1.240 (95% CI 1.154-1.331), respectively. This study showed a significant increase in lung cancer risk among Taiwanese women who were exposed to HPV infection.

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