» Articles » PMID: 27280306

Contextualizing Genetics for Regional Heart Failure Care

Overview
Date 2016 Jun 10
PMID 27280306
Citations 8
Authors
Affiliations
Soon will be listed here.
Abstract

Congestive heart failure (CHF) is a chronic and often devastating cardiovascular disorder with no cure. There has been much advancement in the last two decades that has seen improvements in morbidity and mortality. Clinicians have also noted variations in the responses to therapies. More detailed observations also point to clusters of diseases, phenotypic groupings, unusual severity and the rates at which CHF occurs. Medical genetics is playing an increasingly important role in answering some of these observations. This developing field in many respects provides more information than is currently clinically applicable. This includes making sense of the established single gene mutations or uncommon private mutations. In this thematic series which discusses the many factors that could be relevant for CHF care, once established treatments are available in the communities; this section addresses a contextual role for medical genetics.

Citing Articles

Burden from Study Questionnaire on Patient Fatigue in Qualitative Congestive Heart Failure Research.

Iyngkaran P, Usmani W, Bahmani Z, Hanna F J Cardiovasc Dev Dis. 2024; 11(4).

PMID: 38667714 PMC: 11049876. DOI: 10.3390/jcdd11040096.


Pharmacogenomics Informs Cardiovascular Pharmacotherapy.

Babayeva M, Azzi B, Loewy Z Methods Mol Biol. 2022; 2547:201-240.

PMID: 36068466 DOI: 10.1007/978-1-0716-2573-6_9.


The Wider Considerations in Closing Chronic Disease Gaps - Focus on Heart Failure and Implementation.

Iyngkaran P, Hespe C, Hanna F, Horowitz J, Battersby M, Nelson C Curr Cardiol Rev. 2022; 19(2):e120522204690.

PMID: 35549873 PMC: 10201899. DOI: 10.2174/1573403X18666220512160737.


Deciphering key genes in cardio-renal syndrome using network analysis.

Ahmed M, Tazyeen S, Alam A, Farooqui A, Ali R, Imam N Bioinformation. 2021; 17(1):86-100.

PMID: 34393423 PMC: 8340714. DOI: 10.6026/97320630017086.


Clinical impact of echocardiography parameters and molecular biomarkers in heart failure: Correlation of and polymorphisms with echocardiography parameters: A comparative study.

Suciu-Petrescu M, Truta A, Suciu M, Trifa A, Petrescu D, Rosianu H Exp Ther Med. 2021; 22(1):686.

PMID: 33986851 PMC: 8112153. DOI: 10.3892/etm.2021.10118.


References
1.
Zimmet M . Early impressions of paediatric health in Alice Springs: trying to see beyond the gaps. Med J Aust. 2010; 192(10):606-7. DOI: 10.5694/j.1326-5377.2010.tb03650.x. View

2.
Dirkx E, da Costa Martins P, De Windt L . Regulation of fetal gene expression in heart failure. Biochim Biophys Acta. 2013; 1832(12):2414-24. DOI: 10.1016/j.bbadis.2013.07.023. View

3.
Lester S, Heatley S, Bardy P, Bahnisch J, Bannister K, Faull R . The DD genotype of the angiotensin-converting enzyme gene occurs in very low frequency in Australian Aboriginals. Nephrol Dial Transplant. 1999; 14(4):887-90. DOI: 10.1093/ndt/14.4.887. View

4.
Turner R, Pirmohamed M . Cardiovascular pharmacogenomics: expectations and practical benefits. Clin Pharmacol Ther. 2013; 95(3):281-93. DOI: 10.1038/clpt.2013.234. View

5.
Cannon L, Yu Z, Marciniec T, Waardenberg A, Iismaa S, Nikolova-Krstevski V . Irreversible triggers for hypertrophic cardiomyopathy are established in the early postnatal period. J Am Coll Cardiol. 2015; 65(6):560-9. DOI: 10.1016/j.jacc.2014.10.069. View